Hi all,
As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:
1. Cyproheptadine may have strong anti-cancer properties:
http://www.ncbi.nlm.nih.gov/pubmed/23076705
http://www.ncbi.nlm.nih.gov/pubmed/18502826
2. Cyproheptadine may treat autism:
http://www.ncbi.nlm.nih.gov/pubmed/15068403
http://www.ncbi.nlm.nih.gov/pubmed/12231270
3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
http://www.ncbi.nlm.nih.gov/pubmed/11728834
http://www.ncbi.nlm.nih.gov/pubmed/10319907
4. Cyproheptadine may treat depression and other similar mental issues:
http://www.ncbi.nlm.nih.gov/pubmed/7667171
http://www.ncbi.nlm.nih.gov/pubmed/23442031
http://www.ncbi.nlm.nih.gov/pubmed/9304415
5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
http://www.ncbi.nlm.nih.gov/pubmed/19346455
http://www.ncbi.nlm.nih.gov/pubmed/7976381
6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
http://www.ncbi.nlm.nih.gov/pubmed/7976376
http://www.ncbi.nlm.nih.gov/pubmed/1757225
http://www.ncbi.nlm.nih.gov/pubmed/3982650
7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
http://www.ncbi.nlm.nih.gov/pubmed/8225552
8. Cyproheptadine may protect from endotoxin:
http://www.ncbi.nlm.nih.gov/pubmed/11940385
http://www.ncbi.nlm.nih.gov/pubmed/1598825
http://www.ncbi.nlm.nih.gov/pubmed/8368073
9. Cyproheptadine may stimulate the immune system:
http://www.ncbi.nlm.nih.gov/pubmed/3567337
10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/2995088
11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
http://www.ncbi.nlm.nih.gov/pubmed/2994332
http://www.ncbi.nlm.nih.gov/pubmed/6109449
http://www.ncbi.nlm.nih.gov/pubmed/7017408
http://www.ncbi.nlm.nih.gov/pubmed/115197
http://www.ncbi.nlm.nih.gov/pubmed/4600047
http://www.ncbi.nlm.nih.gov/pubmed/177441
http://www.ncbi.nlm.nih.gov/pubmed/177112
http://www.ncbi.nlm.nih.gov/pubmed/1201741
http://www.ncbi.nlm.nih.gov/pubmed/180050
http://www.ncbi.nlm.nih.gov/pubmed/401824
12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
http://www.ncbi.nlm.nih.gov/pubmed/412631
http://www.ncbi.nlm.nih.gov/pubmed/508004
13. Cyproheptadine may be helpful in the treatment of "alcoholism":
http://www.ncbi.nlm.nih.gov/pubmed/3797491
http://www.ncbi.nlm.nih.gov/pubmed/14157085
14. Cyproheptadine may be helpful in the treatment of "psoriasis":
http://www.ncbi.nlm.nih.gov/pubmed/6735444
15. Cyproheptadine may be helpful in the treatment of decompression sickness:
http://www.ncbi.nlm.nih.gov/pubmed/7233624
16. Cyproheptadine may be helpful in restoring fertility in old age:
http://www.ncbi.nlm.nih.gov/pubmed/1204806
17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
http://www.ncbi.nlm.nih.gov/pubmed/4274414
I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.
Thoughts?
As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:
1. Cyproheptadine may have strong anti-cancer properties:
http://www.ncbi.nlm.nih.gov/pubmed/23076705
http://www.ncbi.nlm.nih.gov/pubmed/18502826
2. Cyproheptadine may treat autism:
http://www.ncbi.nlm.nih.gov/pubmed/15068403
http://www.ncbi.nlm.nih.gov/pubmed/12231270
3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
http://www.ncbi.nlm.nih.gov/pubmed/11728834
http://www.ncbi.nlm.nih.gov/pubmed/10319907
4. Cyproheptadine may treat depression and other similar mental issues:
http://www.ncbi.nlm.nih.gov/pubmed/7667171
http://www.ncbi.nlm.nih.gov/pubmed/23442031
http://www.ncbi.nlm.nih.gov/pubmed/9304415
5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
http://www.ncbi.nlm.nih.gov/pubmed/19346455
http://www.ncbi.nlm.nih.gov/pubmed/7976381
6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
http://www.ncbi.nlm.nih.gov/pubmed/7976376
http://www.ncbi.nlm.nih.gov/pubmed/1757225
http://www.ncbi.nlm.nih.gov/pubmed/3982650
7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
http://www.ncbi.nlm.nih.gov/pubmed/8225552
8. Cyproheptadine may protect from endotoxin:
http://www.ncbi.nlm.nih.gov/pubmed/11940385
http://www.ncbi.nlm.nih.gov/pubmed/1598825
http://www.ncbi.nlm.nih.gov/pubmed/8368073
9. Cyproheptadine may stimulate the immune system:
http://www.ncbi.nlm.nih.gov/pubmed/3567337
10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/2995088
11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
http://www.ncbi.nlm.nih.gov/pubmed/2994332
http://www.ncbi.nlm.nih.gov/pubmed/6109449
http://www.ncbi.nlm.nih.gov/pubmed/7017408
http://www.ncbi.nlm.nih.gov/pubmed/115197
http://www.ncbi.nlm.nih.gov/pubmed/4600047
http://www.ncbi.nlm.nih.gov/pubmed/177441
http://www.ncbi.nlm.nih.gov/pubmed/177112
http://www.ncbi.nlm.nih.gov/pubmed/1201741
http://www.ncbi.nlm.nih.gov/pubmed/180050
http://www.ncbi.nlm.nih.gov/pubmed/401824
12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
http://www.ncbi.nlm.nih.gov/pubmed/412631
http://www.ncbi.nlm.nih.gov/pubmed/508004
13. Cyproheptadine may be helpful in the treatment of "alcoholism":
http://www.ncbi.nlm.nih.gov/pubmed/3797491
http://www.ncbi.nlm.nih.gov/pubmed/14157085
14. Cyproheptadine may be helpful in the treatment of "psoriasis":
http://www.ncbi.nlm.nih.gov/pubmed/6735444
15. Cyproheptadine may be helpful in the treatment of decompression sickness:
http://www.ncbi.nlm.nih.gov/pubmed/7233624
16. Cyproheptadine may be helpful in restoring fertility in old age:
http://www.ncbi.nlm.nih.gov/pubmed/1204806
17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
http://www.ncbi.nlm.nih.gov/pubmed/4274414
I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.
Thoughts?