Objectives: Dihydrotestosterone (DHT) is known as the main cause of androgenetic alopecia (AGA). We previously reported that sulforaphane (SFN), a compound
extracted from broccoli, promotes hair regeneration in ob/ob mice by lowering plasma DHT levels. The aim of this study was to assess whether SFN could decrease
plasma DHT in human.
Methods: We conducted a randomized, double-blind trial to evaluate the effect of SFN on participants following oral intake of SFN-rich broccoli sprouts compared
with alfalfa sprouts (control). Eighty-seven healthy male participants between the ages of 30 and 60 years were divided into two groups: broccoli or alfalfa sprouts
daily intake for one month. Serum testosterone and DHT were determined before and after intervention.
Results: Sixty-eight males were enrolled; 34 in the broccoli sprouts group and 34 in the alfalfa sprouts group. Neither testosterone nor DHT levels were decreased in the broccoli sprouts group. While in the alfalfa sprouts group, testosterone, free testosterone and DHT levels were significantly increased. The change in DHT level of the alfalfa sprouts group was significantly greater than in the broccoli group.
Conclusions: We conducted the study to observe the effect of broccoli sprouts on plasma androgen levels, but there was no effect of broccoli sprouts. We showed that
oral alfalfa sprouts, but not broccoli sprouts, intake could increase plasma androgen levels in males. Alfalfa sprouts intake can be expected to prevent male late onset hypogonadism (LOH). Further research is needed to reveal whether oral SFN (broccoli sprouts) intake can result in improved AGA.
https://www.oatext.com/pdf/JTS-5-283.pdf
extracted from broccoli, promotes hair regeneration in ob/ob mice by lowering plasma DHT levels. The aim of this study was to assess whether SFN could decrease
plasma DHT in human.
Methods: We conducted a randomized, double-blind trial to evaluate the effect of SFN on participants following oral intake of SFN-rich broccoli sprouts compared
with alfalfa sprouts (control). Eighty-seven healthy male participants between the ages of 30 and 60 years were divided into two groups: broccoli or alfalfa sprouts
daily intake for one month. Serum testosterone and DHT were determined before and after intervention.
Results: Sixty-eight males were enrolled; 34 in the broccoli sprouts group and 34 in the alfalfa sprouts group. Neither testosterone nor DHT levels were decreased in the broccoli sprouts group. While in the alfalfa sprouts group, testosterone, free testosterone and DHT levels were significantly increased. The change in DHT level of the alfalfa sprouts group was significantly greater than in the broccoli group.
Conclusions: We conducted the study to observe the effect of broccoli sprouts on plasma androgen levels, but there was no effect of broccoli sprouts. We showed that
oral alfalfa sprouts, but not broccoli sprouts, intake could increase plasma androgen levels in males. Alfalfa sprouts intake can be expected to prevent male late onset hypogonadism (LOH). Further research is needed to reveal whether oral SFN (broccoli sprouts) intake can result in improved AGA.
https://www.oatext.com/pdf/JTS-5-283.pdf