Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Fasoracetam might be especially interesting for people that don't react well to the other racetams and stimulants in generel. I've found that phenylpiracetam can make me a bit irritable, but stacking it with something GABAergic alleviated that.
Or people dealing with anxiety, depression, irritability, insomnia, etc.
This study shows that overtime fasoracetam unregulates the GABA-B receptors . It also shows decreased learned helplessness in one of their tests on mice ,which indicates an anti serotonergic action.
This anti-serotonin effect might be indirect as they state that there's no effect on monoamines. My guess it's proably through increased GABA functioning and thus increased stress tolerance.
"We have previously found that a cognition enhancer [(+)-5-oxo-D-prolinepiperidinamide monohydrate] (NS-105) reversed the inhibition of cyclic AMP formation induced by the GABA(B) receptor agonist baclofen. The GABA(B) receptor has been implicated in the pathophysiology of depressive illness. The present experiment was designed to evaluate the antidepressant activity of NS-105 in the forced swimming and learned helplessness tests in rats. NS-105 (1-100 mg/kg, p.o.) significantly decreased immobility time in the forced swimming test, an effect similar to that of desipramine. Repeated administration of NS-105 also reversed the failure to escape in the shuttle-box test of rats previously exposed to inescapable footshock. Biochemical data showed that repeated administration of NS-105 increased the number of GABA(B) receptors in rat cerebral cortex without affecting the binding properties of beta-adrenoceptors and 5-HT2 receptors. In contrast to other antidepressants, NS-105 did not inhibit monoamine uptake in vitro, nor did it change monoamine concentrations in brain tissues or extracellular fluids. These findings suggest that NS-105, which lacks an effect on monoaminergic systems, has potent antidepressant activity, which may involve up-regulation of GABA(B) receptors after repeated administration.
@Hans you might wanna grab this one too if you haven't made your racetam purchase already:)
Or people dealing with anxiety, depression, irritability, insomnia, etc.
This study shows that overtime fasoracetam unregulates the GABA-B receptors . It also shows decreased learned helplessness in one of their tests on mice ,which indicates an anti serotonergic action.
This anti-serotonin effect might be indirect as they state that there's no effect on monoamines. My guess it's proably through increased GABA functioning and thus increased stress tolerance.
"We have previously found that a cognition enhancer [(+)-5-oxo-D-prolinepiperidinamide monohydrate] (NS-105) reversed the inhibition of cyclic AMP formation induced by the GABA(B) receptor agonist baclofen. The GABA(B) receptor has been implicated in the pathophysiology of depressive illness. The present experiment was designed to evaluate the antidepressant activity of NS-105 in the forced swimming and learned helplessness tests in rats. NS-105 (1-100 mg/kg, p.o.) significantly decreased immobility time in the forced swimming test, an effect similar to that of desipramine. Repeated administration of NS-105 also reversed the failure to escape in the shuttle-box test of rats previously exposed to inescapable footshock. Biochemical data showed that repeated administration of NS-105 increased the number of GABA(B) receptors in rat cerebral cortex without affecting the binding properties of beta-adrenoceptors and 5-HT2 receptors. In contrast to other antidepressants, NS-105 did not inhibit monoamine uptake in vitro, nor did it change monoamine concentrations in brain tissues or extracellular fluids. These findings suggest that NS-105, which lacks an effect on monoaminergic systems, has potent antidepressant activity, which may involve up-regulation of GABA(B) receptors after repeated administration.
Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment - PubMed
We have previously found that a cognition enhancer [(+)-5-oxo-D-prolinepiperidinamide monohydrate] (NS-105) reversed the inhibition of cyclic AMP formation induced by the GABA(B) receptor agonist baclofen. The GABA(B) receptor has been implicated in the pathophysiology of depressive illness. The...
pubmed.ncbi.nlm.nih.gov
@Hans you might wanna grab this one too if you haven't made your racetam purchase already:)