LLight
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- May 30, 2018
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Catecholamine levels in a Ramadan fasting model in rats: a case control study
The results from this study showed statistically significant higher levels of blood DA, but not ADR or NA, in fasting rats, which is indicative of the complexity of the hypothalamic–pituitary–adrenal axis as well as the sympathetic dopaminergic system responses during stress. The sympathetic dopaminergic system response must be more pronounced during fasting. Moreover, the reaction of the dopaminergic system and the non-neuronal gut cells to food intake after fasting may be contributed to the observed higher blood DA levels. Additionally, the higher, but statistically insignificant DA levels in the urine samples of fasting rats may indicate increased renal excretion of DA in satiety and DA synthesized in the kidney. In evaluating the CA levels during fasting, the sympatho-neural, sympatho-adrenomedullary, DOPA–DA autocrine/paracrine and hypothalamic–pituitary–adrenocortical pathways must be taken into consideration.