mayweatherking
Member
- Joined
- Aug 18, 2015
- Messages
- 1,817
I'm trying to fix the problems finasteride causes. I think the allopregnonolone could be fixed via taking pregnenolone and DHEA together:
Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
BACKGROUND:
The neurosteroid allopregnanolone is a potent allosteric modulator of the gamma-aminobutyric acid type A receptor with anxiolytic properties. Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective functioning. However, the neural mechanism whereby allopregnanolone improves mood and reduces anxiety is unknown. In particular, brain imaging has not been used to link neurosteroid effects to emotion regulation neurocircuitry.
METHODS:
To investigate the brain basis of allopregnanolone's impact on emotion regulation, participants were administered 400 mg of pregnenolone (n=16) or placebo (n=15) and underwent 3T functional magnetic resonance imaging while performing the shifted-attention emotion appraisal task, which probes emotional processing and regulation.
RESULTS:
Compared with placebo, allopregnanolone was associated with reduced activity in the amygdala and insula across all conditions. During the appraisal condition, allopregnanolone increased activity in the dorsal medial prefrontal cortex and enhanced connectivity between the amygdala and dorsal medial prefrontal cortex, an effect that was associated with reduced self-reported anxiety.
CONCLUSIONS:
These results demonstrate that in response to emotional stimuli, allopregnanolone reduces activity in regions associated with generation of negative emotion. Furthermore, allopregnanolone may enhance activity in regions linked to regulatory processes. Aberrant activity in these regions has been linked to anxiety psychopathology. These results thus provide initial neuroimaging evidence that allopregnanolone may be a target for pharmacologic intervention in the treatment of anxiety disorders and suggest potential future directions for research into neurosteroid effects on emotion regulation neurocircuitry.
So allopregegnelone is increased via taking pregnenolone. I can say I feel way better after taking it with DHEA. I was going to take progesterone as well, but then I saw progesterone inhibits 5AR2 as well.. I think it would be a bad idea, but I'm not sure yet.
5AR inhibitors also inhibit bile acid synthesis:
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer. There are three isoenzymes of 5-alpha reductase, which vary in different tissues with age.
Can anyone else think of other ways I can get those pathways working again? I think my 5AR2 has been impaired via finasteride or destroyed or something, I'm not sure. But Bile acid I think a lot of coffee has made it work again due to my stool being brown after drinking coffee a lot. But I still think I can't digest protein properly...... I need more of it or something, I don't know.
I'm not sure how to make androgens again though......... I wonder if the pregnenolone over time will increase it along with thyroid and prolactin/PTH being more normal...... any thoughts?
I feel really messed up.. I would like to fix this.
Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
BACKGROUND:
The neurosteroid allopregnanolone is a potent allosteric modulator of the gamma-aminobutyric acid type A receptor with anxiolytic properties. Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective functioning. However, the neural mechanism whereby allopregnanolone improves mood and reduces anxiety is unknown. In particular, brain imaging has not been used to link neurosteroid effects to emotion regulation neurocircuitry.
METHODS:
To investigate the brain basis of allopregnanolone's impact on emotion regulation, participants were administered 400 mg of pregnenolone (n=16) or placebo (n=15) and underwent 3T functional magnetic resonance imaging while performing the shifted-attention emotion appraisal task, which probes emotional processing and regulation.
RESULTS:
Compared with placebo, allopregnanolone was associated with reduced activity in the amygdala and insula across all conditions. During the appraisal condition, allopregnanolone increased activity in the dorsal medial prefrontal cortex and enhanced connectivity between the amygdala and dorsal medial prefrontal cortex, an effect that was associated with reduced self-reported anxiety.
CONCLUSIONS:
These results demonstrate that in response to emotional stimuli, allopregnanolone reduces activity in regions associated with generation of negative emotion. Furthermore, allopregnanolone may enhance activity in regions linked to regulatory processes. Aberrant activity in these regions has been linked to anxiety psychopathology. These results thus provide initial neuroimaging evidence that allopregnanolone may be a target for pharmacologic intervention in the treatment of anxiety disorders and suggest potential future directions for research into neurosteroid effects on emotion regulation neurocircuitry.
So allopregegnelone is increased via taking pregnenolone. I can say I feel way better after taking it with DHEA. I was going to take progesterone as well, but then I saw progesterone inhibits 5AR2 as well.. I think it would be a bad idea, but I'm not sure yet.
5AR inhibitors also inhibit bile acid synthesis:
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer. There are three isoenzymes of 5-alpha reductase, which vary in different tissues with age.
Can anyone else think of other ways I can get those pathways working again? I think my 5AR2 has been impaired via finasteride or destroyed or something, I'm not sure. But Bile acid I think a lot of coffee has made it work again due to my stool being brown after drinking coffee a lot. But I still think I can't digest protein properly...... I need more of it or something, I don't know.
I'm not sure how to make androgens again though......... I wonder if the pregnenolone over time will increase it along with thyroid and prolactin/PTH being more normal...... any thoughts?
I feel really messed up.. I would like to fix this.