Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
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This study shows that GABA increases thyroid hormones that were downregulsted from fluoride ingestion in mice .
This shows what a pro metabolic and protective effect GABA has on the body .
So people drinking high fluoride water might want to stack up on GABA for thyroid protection .
"Subacute injection of sodium fluoride (NaF) decreased blood T4, T3 and thyroid hormone-binding globulin (TBG) levels to 33.98 μg/l, 3 2.8 ng/ml and 11.67 ng/ml, respectively. In addition, fluoride intoxication induced structural abnormalities in thyroid follicles. Our results showed that treatment of fluoride-exposed mice with GABA appreciably decreased metabolic toxicity induced by fluoride and restored the microstructural and ultrastructural organisation of the thyroid gland towards normalcy. Compared with the negative control group, GABA treatment groups showed significantly upregulated T4, T3 and TBG levels (42.34 μg/l, 6.54 ng/ml and 18.78 ng/ml, respectively; P < 0.05), properly increased TSH level and apoptosis inhibition in thyroid follicular epithelial cells."
"Treatment of mice with high concentration of GABA countered the fluoride-induced
alteration of T3 level by 17.7% (P > 0.05), indicating that GABA exerted a better protective
effect than thyroid tablet against fluoride-induced decrease in blood T3 level by restoring
52.9% (P < 0.01) T3 expression compared with that in the NCG."
"TSH levels in the NCG increased significantly by 89.5% (P < 0.01) and were normal
(P > 0.05) in groups receiving high and medium concentrations of GABA (Fig. 1)
compared with those in the control group."
"GABA treatment exerted better
protective effects than thyroid tablets (Fig. 3-c) against fluoride-induced damage of the
ultrastructure of thyroid follicles."
This shows what a pro metabolic and protective effect GABA has on the body .
So people drinking high fluoride water might want to stack up on GABA for thyroid protection .
"Subacute injection of sodium fluoride (NaF) decreased blood T4, T3 and thyroid hormone-binding globulin (TBG) levels to 33.98 μg/l, 3 2.8 ng/ml and 11.67 ng/ml, respectively. In addition, fluoride intoxication induced structural abnormalities in thyroid follicles. Our results showed that treatment of fluoride-exposed mice with GABA appreciably decreased metabolic toxicity induced by fluoride and restored the microstructural and ultrastructural organisation of the thyroid gland towards normalcy. Compared with the negative control group, GABA treatment groups showed significantly upregulated T4, T3 and TBG levels (42.34 μg/l, 6.54 ng/ml and 18.78 ng/ml, respectively; P < 0.05), properly increased TSH level and apoptosis inhibition in thyroid follicular epithelial cells."
"Treatment of mice with high concentration of GABA countered the fluoride-induced
alteration of T3 level by 17.7% (P > 0.05), indicating that GABA exerted a better protective
effect than thyroid tablet against fluoride-induced decrease in blood T3 level by restoring
52.9% (P < 0.01) T3 expression compared with that in the NCG."
"TSH levels in the NCG increased significantly by 89.5% (P < 0.01) and were normal
(P > 0.05) in groups receiving high and medium concentrations of GABA (Fig. 1)
compared with those in the control group."
"GABA treatment exerted better
protective effects than thyroid tablets (Fig. 3-c) against fluoride-induced damage of the
ultrastructure of thyroid follicles."
γ-Aminobutyric acid ameliorates fluoride-induced hypothyroidism in male Kunming mice
This study evaluated the protective effects of γ-aminobutyric acid (GABA), a non-protein amino acid and anti-oxidant, against fluoride-induced hypothy…
www.sciencedirect.com
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