Mary Pruter
Member
- Joined
- Feb 8, 2017
- Messages
- 200
That is sad! And, I'm sure once the drug companies get ahold of it, they'll mess it up!
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By relying too much on fatty acid oxidation, which happens when you are under constant stress. Anf if enough of that fat is PUFA then you get the inflammatory derivatives, which are known to cause AD directly. Look at the 3 links I posted in response to Peater. Niacinamide reportedly succeeded in stopping the progression of AD in a human clinical trial for that reason - inhibiting both lipolysis and fatty acid oxidation.
Safety Study of Nicotinamide to Treat Alzheimer's Disease - Full Text View - ClinicalTrials.gov
I can understand them wanting to make a profit, but that sounds really unethical to not release the information for a treatment that could potentially help current Parkinson's sufferers.
You are saying it stops it but are any studies of this showing it reversing, our patients improving and how long does it take?
Is a liquid glucose product coming ?
Y
You mean dissolved in DMSO? There is probably no need. I may try a liquid ATP instead.
what is liquid atp ?
WoW. Thank you!The human study was based on a mouse study, which used the HED of about 1.5g niacinamide daily. The mouse study actually saw reversal of pathology after 4 months of treatment. The human study used 3g daily AFAIK.
Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau | Journal of Neuroscience
Which is interesting, because Alzeimers for all intensive purposes can be called Type 3 diabetes, or insulin resistance in the brain. Insulin resistance as everyone should know is caused by excess glucose which your cells simply get sick of insulin knocking at the door to let glucose in. Alzeimers is an excess glucose problem which in turns leads to an insulin resistance problem in the brain which leads to glucose deprivation, which ultimately happens because the brain isn't trained to use the safer fuel (ketones) for energy.
To treat this is to simply do the opposite of what one did in the first place; get off glucose dependency, and train your body and brain to use ketones. Or to ensure one has minimal risk at developing alzeimers or some other brain disease in the first place, get off glucose dependency.
Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed
Neuroprotective and disease-modifying effects of the ketogenic diet
The brain consumes about 60% of the body's glucose when a person is physically inactive, and because of its dependence on glucose, it's easily damaged by even short periods of hypoglycemia. Most of its energy is used for a constant restructuring process-it never stops its developmental processes, though their intensity decreases with age. When hypoglycemia occurs during gestation or in infancy, when metabolic intensity is greatest, the adaptations can lead to life-long problem
Starvation and diabetes, in which glucose oxidation is limited, and amino acids and fatty acids are used for fuel, are pseudohypoxic states, forming lactic acid from both glucose and glutamine.
Hypoglycemia, besides causing unconsciousness and shock, can cause grand mal seizures, hypertension, vasospasm, and other excitatory processes, by leading to the release of glutamate and the activation o f the NMDA system.
This excitation creates reductive stress, resembling that in cancer cells, with the activation of the regulatory proteins, including HIF (the hypoxia inducible factor), that reinforce that state of inflammation and lactate produc- tion. Providing extra glucose can lower the HIF.
Ray has said the opposite.
In the newsletter I just got, it contradicts what you are saying.
and
Of course the brain survives ketogenic diets. But does it do well on it?
Nice find, @haidut but, here is a better link:
JCI Insight - The human brain produces fructose from glucose
and
The press release from Yale:
I'm also confused by the "hyperglycemic" conditions.The brain goes to great lengths to create fructose. Note this study was under hyperglycemic conditions. The test subjects (humans) were given 20% dextrose solution. The finding is that glucose turns into fructose in the brain, nothing to do with ketones if I'm understanding correctly.
I'm not a expert but I wonder how they see it this way, the connection may be vice versa, the hyperglycemia itself may be a the product of the factors cause those disorders they mentioned.A growing body of evidence suggests that chronic hyperglycemia leads to many adverse effects on brain function, particularly neurovascular disorders and cognitive impairment
.
I'm also confused by the "hyperglycemic" conditions.