Texon
Member
- Joined
- Nov 28, 2016
- Messages
- 673
@haidut I am not a scientist or doctor, but IMHO these are definitely symptoms of neuroinflammation probably caused by defective tryptophan metabolism. Have you looked into B12 (B12d.org) and thiamine/B1 (Dr. Derrick Lonsdale, MD) deficiencies, which also contain this symptom set? Quinolinic acid is a potent neurotoxin along with glutamate, etc. So not sure you want to reduce kynurenic acid. This is the last thing I would want to do. Current science seems to indicate only 2 pathways, i.e., tryptophan>niacin>nad, OR, tryptophan>quinolinic acid due to lack of nad/disruption of the kynurenine pathway. I share this set of symptoms btw, and it is hellacious trying to get to the bottom of them. I have to be very careful with methyl donors as well. You may want to consider foods such as dairy, all grains and so on as aggravating factors as well. I think these are issues often overlooked.Guys, it’s my last theory and it’s been very encouraging since I started to read about kynurenine pathway.
SSRIs increases KAT activity and reduces KMO activity. This leads to excess ‘kynurenic acid’ and low ‘quinolinic acid’. The first one is a NMDA antagonist, dopamine negative regulator and a7 cholinergic receptor antagonist. The second one is mostly the opposite of it.
I won’t mention all of my problems in this post, in short, I have ‘terrible’ cognitive, emotional and motor dysfunction, also which is progressively worsening day by day.
I seriously need some help. I don’t know if this because a neuroinflammation or a enzyme downregulation, I don’t actually care. I just want to fix them all. I’m open for all suggestions.
New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio. - PubMed - NCBI
- I can’t get any antibitotic without a prescription
- Most of the supplements are unavailable and can’t be ordered from abroad