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- Aug 24, 2017
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Topical.did you suggest progesterone pills?
how much time is it take for you wife to see results?
Immediately.
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Topical.did you suggest progesterone pills?
how much time is it take for you wife to see results?
It does t stain teeth permanently. Takes about 20 min for it to dissipate (I do a drop in an ounce of water and swish it around for a couple min)
Have you considered the selective MAO-A inhibition of methylene blue?
"[...] it is a potent tight binding MAO-A inhibitor at nanomolar concentrations: i.e., it is ~ 100 times more potent than moclobemide" (https://link.springer.com/content/pdf/10.1007/BF03017212.pdf)
And moclobemide is dosed at 450mg/day, sometimes more, which would approximately be equal to 4.5mg of MB if the study is to be believed.
I started a high dose methylene blue protocol about a week ago. I started with 10mg twice a day, then increased the dose by 10mg daily. I wanted to increase the dose until my urine turned green/blue. I hit 100mg dose on the fourth day and then my urine turned blue. So I decreased the dose to 30mg daily, at which I seem to maintain a slight green urine, indicating somewhat of a tissue saturation.
The first day I felt a bit of pressure in my head but nothing too serious. After that, I didn't experience it again. During this period I experienced an increase in energy as well as mood. The mood increase was akin to want to get out more, being more excited, wanting to explore nature, be outside and relax, which I'd say is more dopamine and GABA, compared to serotonin. It's not the same mood effect I get from Tribulus, which is more of a solid feeling, like less anxiety and more confidence. This type of feeling I didn't experience as much with the methylene blue. I also felt mentally shaper and could focus longer.
I started feeling leaner and more fit as well. We're currently treating/fixing my wife's osteoarthritis and the inflammation and water retention around her kneecaps and tailbone area reduced so significantly, she actually looks dry. She is also experiencing improved energy, mood and brain function and reduced overall swelling and joint pains.
Plus, the methylene blue hasn't reduced my vascularity or libido at all, but I'd say it's actually increased. My gut also looks more flat, especially the lower abdomen part.
I'm planning on keeping up with this protocol for some time to come, probably 1-2month more at a minimum, and possibly longer than that, so I'll keep this thread updated if anything changes.
I also ended up adding aspirin at 1g and caffeine at 600mg with my 30mg methylene blue in the morning, so this turned into an uncoupling experiment as well (I added the caffeine and aspirin after I experienced the benefits from methylene blue). I do notice an increase in temperature, but nothing too excessive. If anything, the methylene blue actually increased my heat tolerance, which is nice.
I did feel euphoric and happy on that dose, but I got used to it. I didn't react negatively to it though. After a couple of weeks, maybe 2 months, I reduced the dose to 30mg. I'm currently using around 1mg daily.Nice thread. I am doing something similar, but using oxidal so dosages aren't quite as high in terms of methylene blue. Taking anywhere between 5-10 drops of oxidal a few times a day. Did you lose body fat or just see just less water retention? Keep up the great content and thank you.
I did feel euphoric and happy on that dose, but I got used to it. I didn't react negatively to it though. After a couple of weeks, maybe 2 months, I reduced the dose to 30mg. I'm currently using around 1mg daily.
I did notice a slight reduction in water retention, but nothing wow.
@Beastmode I always sleep well so I can't say any difference there. But I started using MB as a mouth wash and noticed a significant mood lift. I've done a couple weeks on, couple weeks off to test the effect and it's real. My wife can tell when I'm not taking it now.
Now I do 1-2mg a day either under or on top of the tongue depending on how good my aim is.
I don't consume tyramine rich food in general.@Hans Did you restrict tyramine while doing this?
Thanks! But dont you drink milk or eat cheese?I don't consume tyramine rich food in general.
Some interesting fact about methylene blue is that it's a reversible antagonist of MAO-A, which means that if serotonin of tyramine builds up high enough it will displace methylene blue and be broken down. This can help prevent serotonin syndrome.
I can't remember exactly what my diet looked like back then but I'm sure there was milk in there. Not sure how much though. The milk or MB didn't affect me negatively combined.Thanks! But dont you drink milk or eat cheese?