Isadora
Member
- Joined
- Feb 11, 2013
- Messages
- 213
According to this (stunning) article summary, people who had their thyroids (partially) removed could benefit from high TSH level, as TSH rebuilds thyroid tissue...
So they take them off levothyroxine (T4) in order to achieve thyroid reconstruction and the results are pretty amazing!
So... maybe my doctors are right in insisting that I let my TSH go as far as 10 in the hope that my thyroid might regain full function on its own? Would you interpret things in that manner? Or is it wishful thinking on my part?
In this case, I don't know, maybe some of you who are suffering from Hashimoto's might consider not supplementing, after all? And the Peatian thyroid optimization might not be the ideal thing to do under such circumstances?
I'll try to find the full text, for now, here is the abstract:
So they take them off levothyroxine (T4) in order to achieve thyroid reconstruction and the results are pretty amazing!
So... maybe my doctors are right in insisting that I let my TSH go as far as 10 in the hope that my thyroid might regain full function on its own? Would you interpret things in that manner? Or is it wishful thinking on my part?
In this case, I don't know, maybe some of you who are suffering from Hashimoto's might consider not supplementing, after all? And the Peatian thyroid optimization might not be the ideal thing to do under such circumstances?
I'll try to find the full text, for now, here is the abstract:
Influence of the endogene TSH stimulation of thyroid volume increase in the patients after total thyroidectomy due to differentiated thyroid cancer
[Article in Polish]
Pietz L, Michałek K, Waśko R, Ruchała M, Sowiński J.
Source
Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnetrznych, Uniwersytet Medyczny im Karola Marcinkowskiego, Poznan, Poland. [email protected]
Abstract
INTRODUCTION:
The treatment-of-choice for differentiated thyroid carcinoma (DTC) is a total thyroidectomy with subsequent radioiodine therapy. In order to increase an iodine uptake in thyroid tissue remnants, the L-thyroxine withdrawal is required. It is recommended to achieve TSH levels higher than 25 mU/ml. As TSH is a known key factor in thyroid cell proliferation regulation, prolonged stimulation of the cells during L-thyroxine withdrawal can be a causative factor for a re-growth. Our aim was to assess the degree of thyroid re-growth in the patients after total thyroidectomy due to DTC and its possible clinical implications.
MATERIAL AND METHODS:
23 patients operated due to papillary and follicular thyroid cancer were included into the study. Biochemical determinations and ultrasound thyroid imaging were performed (TSH, Tg) during suppressive L-thyroxine therapy as well as 4-5 weeks after the withdrawal.
RESULTS:
The mean volume of thyroid tissue remnants increased after withdrawal for substantial 30.1%. The difference was extremely significant.
CONCLUSIONS:
L-Thyroxine withdrawal in the patients after total thyroidectomy due to DTC can cause re-growth of the tissue remnants. The phenomenon may be of a clinical significance in the selected cases influencing therapeutic decisions.
http://www.ncbi.nlm.nih.gov/pubmed/18465686