Cirion
Member
Found this quote from RP. Confused by the jargon.
Rosacea, inflammation, and aging: The inefficiency of stress
Does this mean we should have hot, or cold coffee then?? All this jargon is going a bit over my head... I read and re-read the paragraph but can't determine if this flushing is a good or bad thing?
Also one thing I have never been able to reconcile is the fact that while caffeine does oppose the effects of adenosine, it also causes the body to create MORE adenosine receptors - which is why one needs more caffeine to feel normal once you start drinking coffee... I argue that so called caffeine "tolerance" is simply the phenomenon of more adenosine receptors therefore needing more caffeine to get the same effect.
I can not count how many times at this point I have brought back coffee and then removed it. It just seems like a net negative to me. If you "need" caffeine, that's ironically when it seems to have the most negative effect on me. Over the weekend I just let myself sleep like 12 hr then I feel good waking up + don't "need" caffeine to wake up.
"The excess excitation that produces nitric oxide and lactic acid lowers the energy production of vascular cells, possibly enough to lower their contractile ability (Geng, et al., 1992), causing vasodilation. When flushing is caused by a mismatch between energy supply and energy demand, caffeine can decrease the vasodilation (Eikvar & Kirkebøen, 1998), but when vasodilation is caused more physiologically by carbon dioxide, caffeine doesn't have that effect (Meno, et al., 2005). In a study in which drinking hot water or coffee was compared with drinking room-temperature coffee or caffeine, it was found that the hot liquids caused flushing, but cool coffee and caffeine didn't.Caffeine increases cells' energy efficiency, and by opposing the effects of adenosine (secreted by cells that are stressed and energy-depleted), it can inhibit vasodilation, angioneogenesis (Merighi, et al., 2007; Ryzhov, et al., 2007), and fibrosis (Chan, et al., 2006). "
Rosacea, inflammation, and aging: The inefficiency of stress
Does this mean we should have hot, or cold coffee then?? All this jargon is going a bit over my head... I read and re-read the paragraph but can't determine if this flushing is a good or bad thing?
Also one thing I have never been able to reconcile is the fact that while caffeine does oppose the effects of adenosine, it also causes the body to create MORE adenosine receptors - which is why one needs more caffeine to feel normal once you start drinking coffee... I argue that so called caffeine "tolerance" is simply the phenomenon of more adenosine receptors therefore needing more caffeine to get the same effect.
I can not count how many times at this point I have brought back coffee and then removed it. It just seems like a net negative to me. If you "need" caffeine, that's ironically when it seems to have the most negative effect on me. Over the weekend I just let myself sleep like 12 hr then I feel good waking up + don't "need" caffeine to wake up.
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