Hypothyroidism (Cortisol, Prolactin And Adrenal Hyperactivity) Causes Balding

[Scenes]

Alright @Travis I’ll bite.

I’ll do the topical wedelolactone for a bit and see. Topical spiro has done nothing for me in the past.

 

[Brandon]

Has anyone tried experimenting with topical use of pomegranate juice? Carbonic anhydrase inhibitor - Wikipedia

Didn’t know that was a carbonic anhydride inhibitor.

 

[Brandon]

so are you using topical vitamin b1 for hair growth ?

not yet, need to start. Right, I just use coconut oil and progest-e .

 

[johnwester130]

You think F.O. Rey is similar to Raymond Peat?

I suppose then you wouldn't mind if I'd start calling you JohnPester130?

anyway,

why would ray peat reccomend a topical carbonic inhibitor for hair loss ? what are the mechanisms for this ?

 

[Brandon]

anyway,

why would ray peat recommend a topical carbonic inhibitor for hair loss? what are the mechanisms for this?

I think Ray Peat views carbonic anhydrase as an important factor in aging. Let me know if this link helps:

Carbonic Anhydrase Is A Key Driver Of Aging; Inhibiting It Is Beneficial

 

[Travis]

anyway,

why would ray peat reccomend [sic] a topical carbonic inhibitor for hair loss ? what are the mechanisms for this ?

He does? Do you have a link which confirms this purported recommendation?

 

[Brandon]

He does? Do you have a link which confirms this purported recommendation?

Carbonic Anhydrase Is A Key Driver Of Aging; Inhibiting It Is Beneficial

 

[Travis]

Carbonic Anhydrase Is A Key Driver Of Aging; Inhibiting It Is Beneficial

That link has no Ray Peat quotes, and mentions the word "hair" not once.

[Edit: I've got it. Johnwester130 provided the link I was looking for below.]

 

[johnwester130]

That link has no Ray Peat quotes, and mentions the word "hair" not once.

...........the person above you emailed peat about baldness and said peat said a topical carbonic inhibitor could be used

Hypothyroidism (Cortisol, Prolactin And Adrenal Hyperactivity) Causes Balding

 

[meatbag]

Danny Roddy tweeted this earlier, thought it was pretty cool;

STIMULATION OF HAIR GROWTH BY TOPICAL APPLICATION OF ANDROGENS.
"Approximately 75% of the [topical testosterone] group showed some stimulation of hair growth, as indicated by longer, thicker, more pigmented hairs in the bald area."

 

[meatbag]

He also tweeted this

Scalp Hair Regrowth in Hormone-Treated Transgender Woman

"Evidence of androgenetic alopecia, or male pattern baldness, can be distressing for transgender women. Here we present the case of a transgender woman with scalp hair regrowth after ∼6 months on oral estradiol and spironolactone therapy achieving testosterone levels within normal female range."

 

[meatbag]

AAAANNNNDDDD this

"Full hair regrowth of a male-to-female transgender using the progesterone-like drug Diane35 ("TwoHen")."

~diane35 is a progestogen (cyproterone acetate+estradiol), what's interesting as compared to spironolactone it doesn't have significant affinity for the MR

 

[Travis]

That Danny Roddy guy seems factual. All of the stuff that I've seen posted from him, on this forum, is in accord with the trends that I've seen myself.

It's not like I'm struggling with hair growth myself, or even trying to sell anything. I am just sharing that observations that I've seen by reading articles on googlescholar.com.

The fact that androgens could stimulate hair growth isn't really surprising, scientifically, but only surprising to the extent that the mass culture has been led to believe the exact opposite.

If that still seems surprising, then the articles of Randall and Thornton will seem downright shocking ():

• Randall, V. A. "Androgens and hair: a biological paradox." Testosterone: action, deficiency, substitution (2004)
• Randall, Valerie A., et al. "The hair follicle: a paradoxical androgen target organ." Hormone Research in Paediatrics (2000)
• Thornton, M. J., et al. "Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells." Clinical endocrinology (1993)
• Thornton, M. J., et al. "Effect of androgens on the growth of cultured human dermal papilla cells derived from beard and scalp hair follicles." Investigative dermatology (1991) [In which it's plainly shown that testosterone stimulates hair growth in scalp cells even more than it does in beard cells (Figure 2).]

 

[tca300]

@Travis @meatbag That diane35 drug which is partly cyproterone, inhibits cortisol and aldosterone.
Effects of Cyproterone Acetate on Adrenal Steroidogenesis in vitro
You are on a roll with your ideas travis! Thank you very much for all the information you share!

 

[johnwester130]

He also tweeted this

Scalp Hair Regrowth in Hormone-Treated Transgender Woman

"Evidence of androgenetic alopecia, or male pattern baldness, can be distressing for transgender women. Here we present the case of a transgender woman with scalp hair regrowth after ∼6 months on oral estradiol and spironolactone therapy achieving testosterone levels within normal female range."

okay.


What would you assume was wrong with the transgender women ?

 

[tca300]

okay.


What would you assume was wrong with the transgender women ?

Low progesterone most likely. It blocks cortisol, aldosterone, and prostaglandins.

 

[meatbag]

That Danny Roddy guy seems factual. All of the stuff that I've seen posted from him, on this forum, is in accord with the trends that I've seen myself.

It's not like I'm struggling with hair growth myself, or even trying to sell anything. I am just sharing that observations that I've seen by reading articles on googlescholar.com.

The fact that androgens could stimulate hair growth isn't really surprising, scientifically, but only surprising to the extent that the mass culture has been led to believe the exact opposite.

If that still seems surprising, then the articles of Randall and Thornton will seem downright shocking ():

• Randall, V. A. "Androgens and hair: a biological paradox." Testosterone: action, deficiency, substitution (2004)
• Randall, Valerie A., et al. "The hair follicle: a paradoxical androgen target organ." Hormone Research in Paediatrics (2000)
• Thornton, M. J., et al. "Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells." Clinical endocrinology (1993)
• Thornton, M. J., et al. "Effect of androgens on the growth of cultured human dermal papilla cells derived from beard and scalp hair follicles." Investigative dermatology (1991) [In which it's plainly shown that testosterone stimulates hair growth in scalp cells even more than it does in beard cells (Figure 2).]

...

Thanks Travis, I remember Ray mentioning topical DHEA for hair growth. I'm assuming there must be a range where it exerts benefits and higher than that would probz be detrimental similarly to how it responds when dosed at 5mg vs 50mg given its various pathways. Probably just low dose oral would be helpful, gonna see what I can find.

 

[johnwester130]

Alright @Travis I’ll bite.

I’ll do the topical wedelolactone for a bit and see. Topical spiro has done nothing for me in the past.

..........................and how on earth do you expect to acquire it ??

 

[Dhair]

That Danny Roddy guy seems factual. All of the stuff that I've seen posted from him, on this forum, is in accord with the trends that I've seen myself.

It's not like I'm struggling with hair growth myself, or even trying to sell anything. I am just sharing that observations that I've seen by reading articles on googlescholar.com.

The fact that androgens could stimulate hair growth isn't really surprising, scientifically, but only surprising to the extent that the mass culture has been led to believe the exact opposite.

If that still seems surprising, then the articles of Randall and Thornton will seem downright shocking ():

• Randall, V. A. "Androgens and hair: a biological paradox." Testosterone: action, deficiency, substitution (2004)
• Randall, Valerie A., et al. "The hair follicle: a paradoxical androgen target organ." Hormone Research in Paediatrics (2000)
• Thornton, M. J., et al. "Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells." Clinical endocrinology (1993)
• Thornton, M. J., et al. "Effect of androgens on the growth of cultured human dermal papilla cells derived from beard and scalp hair follicles." Investigative dermatology (1991) [In which it's plainly shown that testosterone stimulates hair growth in scalp cells even more than it does in beard cells (Figure 2).]

Danny is very meticulous in his research, which is good, because he gets absolutely crucified in hair loss forums for no good reason. Those people are insane though, so I'm sure it doesn't bother him too much.
I have only seen regrowth (confirmed by pictures) from anti-serotonin drugs and red light therapy. These two therapies combined could be powerful and safe enough to regrow hair in a significant number of balding people. It seems to me that reversing fibrosis in the tissue locally should be the #1 priority.

 

[Scenes]

..........................and how on earth do you expect to acquire it ??

I can get that Eclipta alba powder I linked earlier in the thread. Highest source of wedelolactone available.

Travis didn’t say whether the concentration will be great enough to do anything.