Insulin Resistance Cause...?

[Katelove]

I am curious what y'all think of this discussion of insulin resistance...I thought the Randle Cycle explains that fat causes insulin resistance, then I watch this and this feeds my confusion. I have eaten high carb, low fat diet and was losing weight and my insulin levels were coming down but my blood glucose was going very high (over 300 fasting, yes my MD is aware). I am looking for some insights that could help me further.

View: https://www.youtube.com/watch?v=Jd8QFD5Ht18

 

[Serge]

I don't have an opinion on the causes of IR, but this seems to be working very well for me, though further experimenting is necessary: Potato diet and blood sugar experiment

 

[Peatful]

Just in case you haven’t read:

Glucose and sucrose for diabetes.

Diabetes was named for the excessive urination it causes, and for the sugar in the urine. It was called the sugar disease, and physicians were taught that sugar was the problem. Patients were ordered to avoid sweet foods, and in hospitals they were sometimes locked up to keep them from finding...

raypeat.com

Diabetes, scleroderma, oils and hormones

Ray Peat

raypeat.com

Commentary on Type 2 Diabetes – Functional Performance Systems (FPS)

 

[youngsinatra]

High free fatty acids cause insulin resistance via the Randle Effect.

Does not matter if it comes from excess dietary fat or from adipose tissue. I think adipose tissue is a way more significant contributor than dietary fat, especially if a person has eaten a lot of PUFAs in their lifetime and accumulated them in their adipose tissues.

 

[Katelove]

High free fatty acids cause insulin resistance via the Randle Effect.

Does not matter if it comes from excess dietary fat or from adipose tissue. I think adipose tissue is a way more significant contributor than dietary fat, especially if a person has eaten a lot of PUFAs in their lifetime and accumulated them in their adipose tissues.

So then my next question is about when you are losing weight on a low fat diet...do the FFAs that are being released as you lose weight, continue the cycle? Because I have been on a very low fat diet, have 90 lbs or so to lose and was losing weight at about 5 lbs a month...but my fasting blood glucose continued to be very high. My instinct was to keep going, knowing eventually I would lose a lot of fat (although I was losing muscle too, due to low protein) If it takes a year, is it safe to keep going?

 

[Katelove]

So then my next question is about when you are losing weight on a low fat diet...do the FFAs that are being released as you lose weight, continue the cycle? Because I have been on a very low fat diet, have 90 lbs or so to lose and was losing weight at about 5 lbs a month...but my fasting blood glucose continued to be very high. My instinct was to keep going, knowing eventually I would lose a lot of fat (although I was losing muscle too, due to low protein) If it takes a year, is it safe to keep going?

 

[Katelove]

Just in case you haven’t read:

Glucose and sucrose for diabetes.

Diabetes was named for the excessive urination it causes, and for the sugar in the urine. It was called the sugar disease, and physicians were taught that sugar was the problem. Patients were ordered to avoid sweet foods, and in hospitals they were sometimes locked up to keep them from finding...

raypeat.com

Diabetes, scleroderma, oils and hormones

Ray Peat

raypeat.com

Commentary on Type 2 Diabetes – Functional Performance Systems (FPS)

Thank you.

 

[jondoeuk]

View: https://www.youtube.com/watch?v=t-f9Q_-tT68&feature=emb_title



View: https://www.youtube.com/watch?v=Aw8hufhIDu0&feature=emb_title

 

[youngsinatra]

So then my next question is about when you are losing weight on a low fat diet...do the FFAs that are being released as you lose weight, continue the cycle? Because I have been on a very low fat diet, have 90 lbs or so to lose and was losing weight at about 5 lbs a month...but my fasting blood glucose continued to be very high. My instinct was to keep going, knowing eventually I would lose a lot of fat (although I was losing muscle too, due to low protein) If it takes a year, is it safe to keep going?

I don‘t know. I would imagine that such high blood glucose can be very damaging over months and months — to your heart, kidneys and brain. What does your MD think about it?

I‘d possibly consider a different route to lose weight and keep your blood glucose better in check in the meanwhile.

Have you ever considered a ketogenic diet / intermittent fasting regimen to speed up betaoxidation of adipose fat?


View: https://m.youtube.com/watch?v=EsWOXgnk5Ko

 

[Katelove]

I don‘t know. I would imagine that such high blood glucose can be very damaging over months and months — to your heart, kidneys and brain. What does your MD think about it?

I‘d possibly consider a different route to lose weight and keep your blood glucose better in check in the meanwhile.

Have you ever considered a ketogenic diet / intermittent fasting regimen to speed up betaoxidation of adipose fat?


View: https://m.youtube.com/watch?v=EsWOXgnk5Ko

I am confused then about the Randle cycle info if I am eating so much fat on a Keto diet. Is this addressed in this video?

 

[SamYo123]

View: https://www.youtube.com/watch?v=Ee2OTKti_Ec

 

[Kram]

Just my opinion. If you're really trying to lose weight, going with high (lean) protein and lowish carb and fat intake makes the most sense. This will allow your body to go into ketosis and tap into you fat stores (but this isn't optimal long-term). Once the weight has come off, then i'd try slowly increasing carb intake and using things like low dose B1, B3 and pyrucet to lower FFA and shift your cells back to glucose oxidation.

I think it can be hard to lose lots of weight on a high carb diet since your body is focused on burning sugar instead of fat.

 

[Katelove]

Just my opinion. If you're really trying to lose weight, going with high (lean) protein and lowish carb and fat intake makes the most sense. This will allow your body to go into ketosis and tap into you fat stores (but this isn't optimal long-term). Once the weight has come off, then i'd try slowly increasing carb intake and using things like low dose B1, B3 and pyrucet to lower FFA and shift your cells back to glucose oxidation.

I think it can be hard to lose lots of weight on a high carb diet since your body is focused on burning sugar instead of fat.

Thanks Kram. I was losing weight on low fat, high carb, about 5 lbs a month...losing some muscle too though. But anyway, I appreciate your advice. I am considering this...but how do you really find satiation on low carb and low fat? Lean protein and non starchy veg I guess.

 

[Katelove]

Just my opinion. If you're really trying to lose weight, going with high (lean) protein and lowish carb and fat intake makes the most sense. This will allow your body to go into ketosis and tap into you fat stores (but this isn't optimal long-term). Once the weight has come off, then i'd try slowly increasing carb intake and using things like low dose B1, B3 and pyrucet to lower FFA and shift your cells back to glucose oxidation.

I think it can be hard to lose lots of weight on a high carb diet since your body is focused on burning sugar instead of fat.

Thanks Kram. I was losing weight on low fat, high carb, about 5 lbs a month...losing some muscle too though. But anyway, I appreciate your advice. I am considering this...but how do you really find satiation on low carb and low fat? Lean protein and non starchy veg I guess.

 

[Katelove]

View: https://www.youtube.com/watch?v=Ee2OTKti_Ec

I actually was following DurianRider. Sent my blood glucose through the roof! Still hasn't come down for many weeks.

 

[Katelove]

View: https://www.youtube.com/watch?v=Ee2OTKti_Ec

I actually was following DurianRider. Sent my blood glucose through the roof! Still hasn't come down for many weeks.

 

[Katelove]

Sorry I am sending double posts...not sure why

 

[Serge]

I was losing weight on low fat, high carb, about 5 lbs a month...

What do you eat exactly low carb?

 

[Katelove]

What do you eat exactly low carb?

I don't eat low carb. I eat low fat. I eat mostly plant foods, starches, fruit, some sugar. and don't add fat to anything. I was having abou 10g of fat a day.

 

[Serge]

I don't eat low carb. I eat low fat. I eat mostly plant foods, starches, fruit, some sugar. and don't add fat to anything. I was having abou 10g of fat a day.

I meant low fat, sorry. What worked for me is to eat extremely simplistic, 1-2 products only. Took 10 days for the (morning) blood glucose to fall into the almost normal range of a healthy person as opposed to over 180 as it was before. And now I'm going to add one by one product to see what happens. I also eat less than 10g fat. Whaen I was doing high carb eating multiple foods, it never worked for me either.