My hunch is that if you don't want to take too much niacinamide out of balance with other B-vits, you could get some benefit from smaller doses of - eg 50mg or maybe even half that - especially if you had a little several times a day. And the other B-vits too - smaller does, but several times a day.Ok, that makes sense; I will cut back on the Energin. I was taking 40 drops two or three times per day in order to meet RP's recommended 100mg doses of niacinamide. I am leary of taking niacinamide as a stand alone due to the homocysteine raising effect. My theory was that the other B-vitamins in Energin would balance it out, the B6 in particular.