brightside
Member
- Joined
- Aug 9, 2019
- Messages
- 354
Damn, you beat me by 8 minutes hahaDid you check the sections on dosages? The dosages used were massive and would probably produce oxidative stress. See below.
"...Twelve rats were randomly assigned to either a control group (6 rats) or an emodin group (6 rats). Rats in the emodin group were orally administrated with emodin (150 mg/kg daily"
The HED of the above rat dose is about 21.5mg/kg, which means a person weighing 100kg would have to take more than 2g emodin daily to replicate the study design!! At such doses, any quinone is likely to cause damage, even something as "benign" as CoQ10. Another one of the studies you posted even states that the toxicity is dependent on dose.
"...Although emodin in low dose improve hepatic fibrosis4 50 , some studies have reported contradictory findings showing that emodin in high dose is hepatotoxic to normal rats.5 "
Btw, that study with the quote on dose-dependent effects of emodin used even more absurdly high doses of emodin.
"...Forty-eight male Sprague-Dawley (SD) rats (Vital River Laboratories, Beijing, China), 9 weeks of 97 age, were administered high-dose of emodin (1500 mg/kg daily, 100 times the clinical equivalent 98 of rhubarb), medium-dose of emodin (500 mg/kg daily, 33 times the clinical equivalent of 99 rhubarb), low-dose of emodin (150 mg/kg daily"
So, even if somebody were to somehow accidentally ingest the entire Lapodin bottle they won't get anywhere close to even the "low" doses (150mg/kg in rats) those studies used.
@chompie