Low Uric Acid Predictive For Kidney Failure In Young People

[haidut]

Ray has written about the benefits of uric acid as antioxidant. The common medical dogma is that uric acid should be kept as low as possible to avoid thing like gout and kidney disease. This study says that while high uric acid is not a good thing, low uric acid is actually predictive of kidney failure in young people who have no known history of kidney disease.

http://journals.plos.org/plosone/articl ... ne.0118031

"...This study showed that low as well as high levels of uric acid are associated with the loss of kidney function. Hypouricemia is a candidate predictor of kidney function decline in healthy people."

 

[lexis]

Does supplementing molybdenum help ?

 

[haidut]

post 103324 Does supplementing molybdenum help ?

Can you elaborate please? Why would molybdenum be expected to be helpful? The things that raise uric acid most are caffeine, fructose, inosine, uridine, etc.

 

[Parsifal]

 

[natedawggh]

Ray has written about the benefits of uric acid as antioxidant. The common medical dogma is that uric acid should be kept as low as possible to avoid thing like gout and kidney disease. This study says that while high uric acid is not a good thing, low uric acid is actually predictive of kidney failure in young people who have no known history of kidney disease.

http://journals.plos.org/plosone/articl ... ne.0118031

"...This study showed that low as well as high levels of uric acid are associated with the loss of kidney function. Hypouricemia is a candidate predictor of kidney function decline in healthy people."

I'm trying to get off my T3... some things have been slightly helpful, and when I did a stint of progesterone a year ago I was able to go off thyroid for a couple weeks (but taking progesterone long term isn't viable for a male, in the doses needed to induce thyroid function). I have been taking inosine, and have a slight difference in pulse from 55 bpm without inosine to 75 bpm with it. I think the rise is significant enough to seem promising. Ray said that in hypothyroidism the corresponding rise in cortisol and adrenaline lower the production of uric acid. But whether it would have long term benefits I'm not sure. Have you taken Inosine? I also find that my sleep comes more quickly on inosine, but it doesn't have an effect on my temperature that I can tell.

 

[haidut]

I'm trying to get off my T3... some things have been slightly helpful, and when I did a stint of progesterone a year ago I was able to go off thyroid for a couple weeks (but taking progesterone long term isn't viable for a male, in the doses needed to induce thyroid function). I have been taking inosine, and have a slight difference in pulse from 55 bpm without inosine to 75 bpm with it. I think the rise is significant enough to seem promising. Ray said that in hypothyroidism the corresponding rise in cortisol and adrenaline lower the production of uric acid. But whether it would have long term benefits I'm not sure. Have you taken Inosine? I also find that my sleep comes more quickly on inosine, but it doesn't have an effect on my temperature that I can tell.

Inosine is an adenosine agonist and thus is expected sleepy. So, combining inosine with caffeine maybe a good idea to balance some of its jittery and insomnia side effects. Inosine lowers adrenaline and as such is used as a heart protective and blood pressure lowering agent by some athletes.

 

[yerrag]

This is good to know. I've had hypertension for 12 years already and I found out 6 years ago that it was due to lead toxicity. I took an oral chelation protocol called HMD but that turned out to be a dud. I had given up practically after trying out different ways of lowering my blood pressure. Then this year I started using PectaClear for oral chelation and I'm getting improvements on my blood pressure. My uric acid level was high as well all this time, but with the oral chelation I'm taking now it has been getting lower as well.

I think the uric acid was protecting me all this time, to keep my kidney from deteriorating further. Last test I took of my urine, it had protein (likely albumin) and it indicated I am on Stage 1 chronic kidney disease. I would go out on a limb to say that the lead toxicity in my kidney would have been worse if I had taken blood pressure medication. My tissues had to be in a state of hypoxia for uric acid to be created, and to create that condition, my blood vessels had to be constricted. And constricted blood vessels increase blood pressure. I guess it was my body's way of adapting to the need to protect me from the harm of lead in my kidney, and by increasing uric acid I was being protected from excessive oxidation by free radicals.

In this article of Functional Performance Systems, it says many good things about uric acid:

Uric Acid as an Antioxidant – Functional Performance Systems (FPS)

One of the references even show that uric acid is even more protective than Vitamin C:

J Cardiovasc Pharmacol. 2001 Sep;38(3):365-71.
Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers.
Waring WS, Webb DJ, Maxwell SR.
Oxidative stress plays an important role in the development of atherosclerosis and contributes to tissue damage that occurs as a consequence, particularly in myocardial infarction and acute stroke. Antioxidant properties of uric acid have long been recognized and, as a result of its comparatively high serum concentrations, it is the most abundant scavenger of free radicals in humans. Elevation of serum uric acid concentration occurs as a physiologic response to increased oxidative stress-for example, during acute exercise-thus providing a counter-regulatory increase in antioxidant defenses. In view of its antioxidant properties, uric acid may have potentially important and beneficial effects within the cardiovascular system. We wished to investigate whether administration of uric acid was feasible and if it could have an impact on antioxidant function in vivo. We have, therefore, performed a randomized, placebo-controlled double-blind study of the effects of systemic administration of uric acid, 1,000 mg, in healthy volunteers, compared with vitamin C, 1,000 mg. We observed a significant increase in serum free-radical scavenging capacity from baseline during uric acid and vitamin C infusion, using two methodologically distinct antioxidant assays. The effect of uric acid was substantially greater than that of vitamin C.

It would be helpful for me later to show my improvements as far as kidney is concerned. I will have to provide over time some markers to go with my kidney's recovery. I'll need albumin-creatinine ratio (ACR) to gauge the condition of my kidney, and then provide information such as blood pressure, and my uric acid levels. My goal is to show that as my kidney improves, my blood pressure would lower to a normal level, and that my uric acid levels would decrease, the decrease being the resultant of a lesser need for it to protect my kidney.

 

[yerrag]

Can you elaborate please? Why would molybdenum be expected to be helpful? The things that raise uric acid most are caffeine, fructose, inosine, uridine, etc.

Molybdenum

The biological form of the molybdenum atom is an organic molecule known as the molybdenum cofactor (Moco) present in the active site of Moco-containing enzymes (molybdoenzymes) (2). In humans, molybdenum is known to function as a cofactor for four enzymes:

...

• Xanthine oxidase catalyzes the breakdown of nucleotides (precursors to DNA and RNA) to form uric acid, which contributes to the plasma antioxidant capacity of the blood. ...

 

[Mastemah]

Molybdenum

The biological form of the molybdenum atom is an organic molecule known as the molybdenum cofactor (Moco) present in the active site of Moco-containing enzymes (molybdoenzymes) (2). In humans, molybdenum is known to function as a cofactor for four enzymes:

...

• Xanthine oxidase catalyzes the breakdown of nucleotides (precursors to DNA and RNA) to form uric acid, which contributes to the plasma antioxidant capacity of the blood. ...

I asked Ray about molybdenum and he said you can get enough from liver, shrimp, mushroom...

 

[golder]

I'm trying to work out if my uric acid levels which are above the upper limit of the reference range is something to be concerned about?
My result was 453umol/L (range 200-430)
I know Ray regards it as fundamental to our antioxidant system, but I assume there is a point of diminishing returns?
Thanks if anyone can give me their opinion :)

 

[yerrag]

It's high, but only because you have a condition that needs more uric acid to protect you. That condition produces a higher than normal level of oxidative stress, and so your uric acid is higher than normal as well. In my case, my urine uric acid levels are very low, which means the body is retaining more uric acid, keeping it from being excreted, in order to increase uric acid levels.

As long as your acid base balance is optimal, and that you don't get to become acidic (ecf} you don't have to worry about developing uric acid crystals that precipitate out and accumulate in joints, causing arthritis and gout. And a good way to guarantee that is to have optimal mitochondrial metabolism.

But you have to find out what is that condition you have that causes you to need extra protection from increased uric acid levels. This is not an easy task though, as conventional know zero about this. Nor do many holistic practitioners.

 

[aliml]

URICOSURIC

An agent that increases the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma.

Aucubin
Boldine
Glycine
Salicylates
Thymoquinone

URICOGENIC

An agent that promotes breakdown of purines in the body, which leads to production of uric acid.

Inosine
Sucrose

 

[golder]

URICOSURIC

An agent that increases the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma.

Aucubin
Boldine
Glycine
Salicylates
Thymoquinone

URICOGENIC

An agent that promotes breakdown of purines in the body, which leads to production of uric acid.

Inosine
Sucrose

Thanks man. Looks like high glycine would be a good temporary measure to slightly speed up excretion whilst I work on the much more difficult to task of working out why it’s elevated to start with! Much appreciated

 

[aliml]

Thanks man. Looks like high glycine would be a good temporary measure to slightly speed up excretion whilst I work on the much more difficult to task of working out why it’s elevated to start with! Much appreciated

High Levels of Uric Acid​

1) Diets High in Purines​

Diets high in purines (e.g meat, seafood, soybeans) and fructose increase uric acid levels [20, 21, 22, 23, 24, 25, 26].

In a crossover study, the effect of ingesting some purine-rich foods like beef liver, haddock fillets, and soybean was investigated. Results showed that the ingestion of all the test meals caused an increase in blood uric acid levels [21].

Studies have found that each additional meat portion per day increases the risk of gout by 21% [20].

Fructose rapidly raises uric acid levels. High dietary intake of fructose in foods and drinks increase the production of inosine and purines. Also, fructose competes with uric acid for secretion in the kidney [27, 28].

In addition, fructose stimulates uric acid synthesis from amino acid precursors, such as glycine [29].

2) Obesity​

According to a population-based study, obesity is associated with an increased risk of developing hyperuricemia (elevated uric acid). If you are overweight, your body produces more uric acid. And, as a result, the kidney has a more difficult time eliminating uric acid [30].

Blood uric acid levels correlate with leptin levels. Since obese individuals have higher leptin levels (due to leptin resistance), high leptin may be linked to the development of hyperuricemia in obesity [31].

3) Dehydration​

Uric acid levels increase with dehydration, mainly because there is less water in the body and the blood becomes more concentrated [32, 33]. Levels return back to normal after hydrating.

4) Fasting and Ketogenic Diet​

Fasting and ketosis that often occurs in fasting increase uric acid levels [34, 35, 36, 37].

A ketogenic diet reduces the ability of the kidney to excrete uric acid because of competition for transport between uric acid and ketones [37].

5) Rapid Weight Loss​

In the short term, rapid weight loss can increase uric acid levels [38, 39].

In a study of obese people who underwent gastric bypass surgery, uric acid levels and gout attacks initially increase after surgery. However, these people ultimately had lower inflammation and benefited from weight loss [39].

6) Alcohol​

According to a population-based study, alcohol-related diseases were significantly associated with gout risk. Also, severe alcohol-dependent patients had an increased risk of gout [40].

Alcohol may stimulate uric acid production by increasing lactic acid, which then reduces the excretion of uric acid in the kidneys [41].

Also, alcohol accelerates the breakdown of purines, thereby increasing the production of uric acid [42, 43].

7) Vitamin D deficiency​

In a study of 1.7k women over 30, postmenopausal women with vitamin D insufficiency (low levels) were more likely to have higher uric acid levels [44].

A genetic study suggests that there may be a causal link between vitamin D deficiency and elevated uric acid levels, but this requires further confirmation [45].

8) Kidney Disease​

Higher levels of uric acid occur when the kidneys don’t eliminate uric acid efficiently [3].

9) Thyroid and Parathyroid Disorders​

Both thyroid and parathyroid disorders can result in elevated uric acid levels [46, 47, 48, 49].

In hyperthyroidism (overactive thyroid) more uric acid is being made, while in hypothyroidism (underactive thyroid) the uric acid increases due to impaired kidney function [46].

Elevated blood parathyroid hormone levels are associated with higher blood uric acid levels in the general population. Although exact mechanisms are unclear, it is thought that parathyroid hormone increases blood uric acid by reducing kidney urate excretion [48, 50].

However, there are also reports of elevated uric acid in some cases of hypoparathyroidism (low parathyroid hormone levels) [51].

10) Lead Poisoning​

Lead exposure is associated with impaired kidney function and increased blood uric acid levels [52, 53, 54].

High levels of lead damage the kidneys, causing inflammation and inhibiting uric acid excretion, which results in urate build-up and eventually, saturnine gout (i.e., lead gout) [55].

11) Genetic Disorders​

People with some rare genetic disorders (Lesch-Nyhan syndrome, Kelley-Seegmiller syndrome) have elevated uric acid levels, due to mutations in the HPRT gene [56, 57].

People with mutations in other genes such as UCP2, SLC2A9, ABCG2, SLC17A1 or SLC17A3, can also have higher uric acid levels [58, 59].

People with down syndrome consistently have higher blood uric acid levels [60].

12) Medication​

Many drugs can increase blood uric acid levels, including:

• Water pills (diuretics) [61, 62]
• Chronic use of low-dose aspirin 61]
• Nicotinic acid (niacin) [61, 63]
• Medications that suppress the immune system (immunosuppressants) [61, 64, 65]
• Chemotherapy, by causing tumor lysis syndrome [61, 66, 67, 68]
• Sildenafil (Viagra) [61, 69]
• Testosterone [61, 70]

13) Lack of Estrogen/Male Gender​

Estrogen is required for the normal elimination of urate through the kidneys.

Men have higher blood uric acid levels than premenopausal women and are more at risk for developing gout [71].

During the post-menopausal period, women have the same content of uric acid as men of similar age, suggesting that low estrogen may have a role in decreasing uric acid levels [71].

Causes of High Uric acid, Associated Problems + Ways to Decrease - SelfDecode Labs

A uric acid test can evaluate your risk of kidney stones, gout, and more. Read on to learn more about uric acid & how to decrease it here.

labs.selfdecode.com

 

[golder]

Great detail, thanks. Looks like I won’t be trying more glycine:

‘’In addition, fructose stimulates uric acid synthesis from amino acid precursors, such as glycine [29].’’

 

[aliml]

Great detail, thanks. Looks like I won’t be trying more glycine:

‘’In addition, fructose stimulates uric acid synthesis from amino acid precursors, such as glycine [29].’’

Glycine, a non-essential amino acid, was revealed to enhance the urinary excretion of uric acid in healthy subjects as well as in patients with gout in previous studies [11,12,13].

Combined Supplementation with Glycine and Tryptophan Reduces Purine-Induced Serum Uric Acid Elevation by Accelerating Urinary Uric Acid Excretion: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

The authors previously confirmed the serum uric acid-lowering effects of the combination of glycine and tryptophan in subjects with mild hyperuricemia. This study examined whether combined supplementation with glycine and tryptophan suppressed the elevation ...

www.ncbi.nlm.nih.gov

 

[Peatress]

Low uric acid: causes, symptoms and treatment - Fastlyheal

Uric acid is a substance produced by our body when it breaks down purines from food and beverages and is expelled through the urine and feces to a lesser

fastlyheal.com

 

[Peatress]

Would cardonosine be good for raising uric acid @haidut ?

​