IhateFin
Member
- Joined
- Jul 25, 2017
- Messages
- 60
It has been theorized that finasteride may cause a perminant suppression of 5alpha reductase but I was curious as to why. I also have read many theories that finasteride is capable of changing gene expression and I stumbled on to this article
Abstract 1052: Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation | Cancer Research
What if finasteride triggers this same hyper methylation of 5alpha reductase thus silencing it? In this article it stated that treatment with inhitors of this process are able to "reactivate" 5alpha reductase.
The drug that stops the methylation process is azacitidine, but seems super dangerous.
I read an article to stating that 2 polyphenals in caffeine imhibit the methylation too.
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. - PubMed - NCBI
Is this the reason it increases 5AR activity?
With information like this what would one recommend in terms of things to research to reduce the gene triggered silence of the 5AR enzyme?
This may not be news to anyone but I thought it was a pretty decent find. I am going to be taking 200mg caffeine pills in hopes to safely inhibit this process and reactivate 5AR.
Abstract 1052: Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation | Cancer Research
What if finasteride triggers this same hyper methylation of 5alpha reductase thus silencing it? In this article it stated that treatment with inhitors of this process are able to "reactivate" 5alpha reductase.
The drug that stops the methylation process is azacitidine, but seems super dangerous.
I read an article to stating that 2 polyphenals in caffeine imhibit the methylation too.
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. - PubMed - NCBI
Is this the reason it increases 5AR activity?
With information like this what would one recommend in terms of things to research to reduce the gene triggered silence of the 5AR enzyme?
This may not be news to anyone but I thought it was a pretty decent find. I am going to be taking 200mg caffeine pills in hopes to safely inhibit this process and reactivate 5AR.
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