Mauritio
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- Feb 26, 2018
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This study has some commonalities and some differences from the original study of this thread.
It showed that low dose nicotine resulted in worse reproductive health in male rats.
However the dosage was about 3-4 times higher, about 7,5mg per day and since it was IP the oral dose to achieve that level would be around 10mg.
The dose was given intraperitoneally, all ot once , as opposed to the slow and steady approach from the OP-study, so that might be another reason why these studies had a different outcome.
Plus, I doubt intraperitoneal administration has the same first pass metabolism than oral admin has. The nicotine metabolites like cotinine might play a role in its benefits.
" A low-dose nicotine exposure at 0.6 mg/kg caused detrimental effects on sperm characteristics and induced oxidative stress in the testes and prostate."
It showed that low dose nicotine resulted in worse reproductive health in male rats.
However the dosage was about 3-4 times higher, about 7,5mg per day and since it was IP the oral dose to achieve that level would be around 10mg.
The dose was given intraperitoneally, all ot once , as opposed to the slow and steady approach from the OP-study, so that might be another reason why these studies had a different outcome.
Plus, I doubt intraperitoneal administration has the same first pass metabolism than oral admin has. The nicotine metabolites like cotinine might play a role in its benefits.
" A low-dose nicotine exposure at 0.6 mg/kg caused detrimental effects on sperm characteristics and induced oxidative stress in the testes and prostate."
Low-dose Nicotine Exposure Induced the Oxidative Damage of Reproductive Organs and Altered the Sperm Characteristics of Adolescent Male Rats - PubMed
A low-dose nicotine exposure at 0.6 mg/kg caused detrimental effects on sperm characteristics and induced oxidative stress in the testes and prostate.
pubmed.ncbi.nlm.nih.gov