LeeLemonoil
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- Sep 24, 2016
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Meat Intake and the Dose of Vitamin B3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?
We will argue that nobody ever systematically checked that pellagra was eliminated globally (dietary supplementation mainly happened in rich countries). Pellagra may be common and misdiagnosed masquerading as ‘environmental enteropathy’, poor cognition, eczema, or general ill health and a lack of well-being or poor homeostasis when under environmental stress with shortened lives.38,39
We also argue that environmental insults from trauma, hypoxia, toxins, stress, or mutations (such as in mitochondrial or DNA-repair genes) may require either lifetime or temporary higher doses than normally recommended (15 mg/d).
Controversially, we suggest that many people in rich countries may be on too high a dose. A hyper-vitaminosis B3 state may be common and, like pellagra, have a wide phenotype that includes the metabolic syndrome, several cancers, and some degenerative or neuro-behavioural disorders.40
Furthermore, we propose that the transition from diseases of poverty to diseases of affluence is due to switching the dose of meat/nicotinamide too fast and too far.41,42 The most recent version of the ‘hygiene hypothesis’ concentrates on reductions in symbiotic/commensal biome diversity acquired early in development, not cleanliness during childhood and common pathogens.43–46 We will discuss how a biochemical switch away from the need to produce nicotinamide ‘in house’ from tryptophan, and the related reduced metabolic need for gut symbionts or tuberculosis (TB) on a better diet so that they are no longer ‘welcomed’ by the immune system is a more plausible explanation for the loss of microbial ‘old friends’. This switch of microbiomes reduces tolerogenic instruction to the immune system further encouraging it to over-react to otherwise irrelevant foreign proteins or self-proteins.47
We will argue that nobody ever systematically checked that pellagra was eliminated globally (dietary supplementation mainly happened in rich countries). Pellagra may be common and misdiagnosed masquerading as ‘environmental enteropathy’, poor cognition, eczema, or general ill health and a lack of well-being or poor homeostasis when under environmental stress with shortened lives.38,39
We also argue that environmental insults from trauma, hypoxia, toxins, stress, or mutations (such as in mitochondrial or DNA-repair genes) may require either lifetime or temporary higher doses than normally recommended (15 mg/d).
Controversially, we suggest that many people in rich countries may be on too high a dose. A hyper-vitaminosis B3 state may be common and, like pellagra, have a wide phenotype that includes the metabolic syndrome, several cancers, and some degenerative or neuro-behavioural disorders.40
Furthermore, we propose that the transition from diseases of poverty to diseases of affluence is due to switching the dose of meat/nicotinamide too fast and too far.41,42 The most recent version of the ‘hygiene hypothesis’ concentrates on reductions in symbiotic/commensal biome diversity acquired early in development, not cleanliness during childhood and common pathogens.43–46 We will discuss how a biochemical switch away from the need to produce nicotinamide ‘in house’ from tryptophan, and the related reduced metabolic need for gut symbionts or tuberculosis (TB) on a better diet so that they are no longer ‘welcomed’ by the immune system is a more plausible explanation for the loss of microbial ‘old friends’. This switch of microbiomes reduces tolerogenic instruction to the immune system further encouraging it to over-react to otherwise irrelevant foreign proteins or self-proteins.47