Sounds like Glycine, L-Cartinine and Creatine should be my best friends!
I did some digging and found this interest excerpt:
“In order to bolster a particular pathway, cells can increase the amount of a necessary (rate-limiting) enzyme or use activators to convert that enzyme into an active conformation. Conversely, to slow down or halt a pathway, cells can decrease the amount of an enzyme or use inhibitors to make the enzyme inactive.
Such up- and down-regulation of metabolic pathways is often a response to changes in concentrations of key metabolites in the cell. For example, a cell may take stock of its levels of intermediate metabolites and tune the glycolytic pathway and the synthesis of glucose accordingly.”
Source: Cell Metabolism
It seems as though the cell (and specifically the cell) can take stock of the substrates available for certain metabolic pathways, therefore it would seem that the best way to upregulate 5ar activity would be get as much testosterone into cells as possible.
I wonder what metabolic pathways oppose 5ar other than Aromatase as like you said, the body could have established a new homeostasis, therefore the cell says to itself “well we don’t need to make much 5ar as we’ve already created all the DHT we‘re now used to making” so it sends it all off down the aromatase pathway. Therefore by removing every other metabolic pathway, the cell would be forced to create 5ar to metabolise the testosterone??
However issue with that thought is, whether the cell even lets the test into the cell to be metabolised, as it might now be used to not needing that much test as it doesn’t need that much DHT - think it’s called osmosis (the management of infra/extra cell concentrations).
Also going to look into how Glycine/L-Cartinine and Creatine boost 5ar upregulation, as if I can understand that mechanism I might be able to maximise the efficiency or find other substances that do it even better.
I did some digging and found this interest excerpt:
“In order to bolster a particular pathway, cells can increase the amount of a necessary (rate-limiting) enzyme or use activators to convert that enzyme into an active conformation. Conversely, to slow down or halt a pathway, cells can decrease the amount of an enzyme or use inhibitors to make the enzyme inactive.
Such up- and down-regulation of metabolic pathways is often a response to changes in concentrations of key metabolites in the cell. For example, a cell may take stock of its levels of intermediate metabolites and tune the glycolytic pathway and the synthesis of glucose accordingly.”
Source: Cell Metabolism
It seems as though the cell (and specifically the cell) can take stock of the substrates available for certain metabolic pathways, therefore it would seem that the best way to upregulate 5ar activity would be get as much testosterone into cells as possible.
I wonder what metabolic pathways oppose 5ar other than Aromatase as like you said, the body could have established a new homeostasis, therefore the cell says to itself “well we don’t need to make much 5ar as we’ve already created all the DHT we‘re now used to making” so it sends it all off down the aromatase pathway. Therefore by removing every other metabolic pathway, the cell would be forced to create 5ar to metabolise the testosterone??
However issue with that thought is, whether the cell even lets the test into the cell to be metabolised, as it might now be used to not needing that much test as it doesn’t need that much DHT - think it’s called osmosis (the management of infra/extra cell concentrations).
Also going to look into how Glycine/L-Cartinine and Creatine boost 5ar upregulation, as if I can understand that mechanism I might be able to maximise the efficiency or find other substances that do it even better.