curious_anthro
Member
My quest to understand my health issues continues and has led to connect several dots and question if perhaps some sort of pituitary dysfunction is driving my symptoms. But its not a clear picture, in fact it seems contradictory based on my current (albeit limited) understandings.
Testing over the years has revealed:
- Low DHEA-S (blood)
- Low FSH / normal LH (blood)
- Low progesterone, low estradiol, estrone, estriol (urine and blood)
- Normal cortisol (urine and blood)
- Normal prolactin (blood)
- TSH 1.9 - 2.17 mIU/L (blood)
My main symptoms: the absolute worst one is cystic acne on face, back and chest, hot flashes (at only 30 year old), insomnia, mild hirusitism, fatigue during the day, brain fog/poor concentration
Consistently negative reactions to highly recommended supplements, for example:
- Aspirin: muscle weakness, extreme fatigue during the day yet restlessness/insomnia at night
- Vitamin D (in EVOO applied on skin or oral): extreme hot flashes, nausea, brain fog, depression
- Vitamin K: same reaction as aspirin
- Cyproheptadine: at doses of 0.5mg, increased acne, zero motivation and depression/weepy
- vitamin E: cystic acne breakouts get worse, nausea
- b-vitamins: hard energy crash in the evenings, other than that notice no real benefits and tried several high quality formulas
- Methylene Blue: amazing energy for a few hours then hard crash and severe nightmares (1 - 1.5 mg)
- caffeine: hard energy crash, cold hands/feet and anxiety no matter how much I eat with it or what time I have the caffeine
I have really focused on healing my gut thinking that was the main driver and had some initial success but then everything got worse again despite maintaining the things that did work. I feel like most people on this forum ask about high FSH, high DHEA, high cortisol.... but my tests always show these are low! Then everything I take that drives estrogen and cortisol down, seems to make things worse. And I thought thyroid and pituitary have an inverse relationship but I feel like I am both hypopituitary and hypothyroid?! I have also been taking progesterone (progest-E and topical), trying both moderate and massive doses, for one year and sometimes it feels like its helping and sometimes not no matter the dose. Interestingly as a child, I had really brittle bones, sleep issues, extremely low weight and delayed onset of puberty which has led me to wonder if there is something going on with my pituitary.
Does anyone have any similar experiences/results or good understanding of how pituitary dysfunction manifests? I sincerely appreciate any and all help or advice!
Testing over the years has revealed:
- Low DHEA-S (blood)
- Low FSH / normal LH (blood)
- Low progesterone, low estradiol, estrone, estriol (urine and blood)
- Normal cortisol (urine and blood)
- Normal prolactin (blood)
- TSH 1.9 - 2.17 mIU/L (blood)
My main symptoms: the absolute worst one is cystic acne on face, back and chest, hot flashes (at only 30 year old), insomnia, mild hirusitism, fatigue during the day, brain fog/poor concentration
Consistently negative reactions to highly recommended supplements, for example:
- Aspirin: muscle weakness, extreme fatigue during the day yet restlessness/insomnia at night
- Vitamin D (in EVOO applied on skin or oral): extreme hot flashes, nausea, brain fog, depression
- Vitamin K: same reaction as aspirin
- Cyproheptadine: at doses of 0.5mg, increased acne, zero motivation and depression/weepy
- vitamin E: cystic acne breakouts get worse, nausea
- b-vitamins: hard energy crash in the evenings, other than that notice no real benefits and tried several high quality formulas
- Methylene Blue: amazing energy for a few hours then hard crash and severe nightmares (1 - 1.5 mg)
- caffeine: hard energy crash, cold hands/feet and anxiety no matter how much I eat with it or what time I have the caffeine
I have really focused on healing my gut thinking that was the main driver and had some initial success but then everything got worse again despite maintaining the things that did work. I feel like most people on this forum ask about high FSH, high DHEA, high cortisol.... but my tests always show these are low! Then everything I take that drives estrogen and cortisol down, seems to make things worse. And I thought thyroid and pituitary have an inverse relationship but I feel like I am both hypopituitary and hypothyroid?! I have also been taking progesterone (progest-E and topical), trying both moderate and massive doses, for one year and sometimes it feels like its helping and sometimes not no matter the dose. Interestingly as a child, I had really brittle bones, sleep issues, extremely low weight and delayed onset of puberty which has led me to wonder if there is something going on with my pituitary.
Does anyone have any similar experiences/results or good understanding of how pituitary dysfunction manifests? I sincerely appreciate any and all help or advice!