Texon
Member
- Joined
- Nov 28, 2016
- Messages
- 673
@Regina Travis this is very interesting in that I tried a DIM supplement one time and thought I had poisoned myself. So that was that as they say. Plus I only recently discovered that b6 vitamin can help with both excess glutamate metabolism and the bad side of tryptophan metabolism i.e. quinolinic acid both of which I deal with. This has been a long process of discovery that I think would have taken a very rare doctor to diagnose.I do know the bacteria that had been used to synthesize tryptophan—genetically engineered for greater output—also had produced novel indole metabolites. However: the concentrations were quite very low if I remember correctly, and there's also reason to suppose plain tryptophan could do this. Individuals will naturally convert tryptophan into serotonin, tryptophol, 5-hydroxytryptophol, and 5-hydroxyindoleacetic acid at different rates than others. The relative amounts of each species ultimately created depends on niacin intake, cortisol concentrations, γ-interferon titer, muscle catabolism, ethanol intake, and liver expression of such enzymes as: alcohol dehydrogenase, tryptophan 2,3-dioxygenase, and monoamine oxidase. Cytokine profiles and presence of other plasma chemotactic factors could help determine eventual eosinophil counts, and even something as simple as a cyclooxygenase inhibitor can increase leukotriene B₄ by sparing arachidonic acid (20∶4ω−6). Fatty acid ratios could also play a part: This is because leukotriene B₅—made from eicosapentaenoic acid (20∶5ω−3)—is about 5,000 × less potent than leukotriene B₄ while the Mead acid (20∶3ω−9) product, leukotriene B₃, is comparatively-ineffectual by roughly fivefold. I believe biology is largely deterministic, should we ever know enough, but since there exists so many biochemical factors the rare conditions can almost appear to strike at random. I believe that you've found a good forum, and this because Ray Peat emphasizes the avoidance of linoleic acid (18∶2ω−6)—the precursor for arachidonic acid. However: I would avoid cyclooxygenase inhibitors because they increase leukotriene B₄, another powerful chemotactic for for eosinophils (Nagy, 1982). Baicalein is the classic lipoxygenase inhibitor, and it also has been shown to reduce eosinophil and eotaxin concentrations (He, 2011).