Thank you again for your reply! I also might take twice daily if it is a tough day. Thrilled to read your posts. I so believe in Progest-e.I am pretty generous with it-- mostly squirt in onto my lower gums (maybe 4 "drops"?) a couple times per day; but depending upon what is going on, I could do more. I also tend to use less of it through and up to day 13 of my cycle ( I might just use it once per day during the week after end of menstruation) and more of it on days 14 up to first day of next menstuation in order to emulate the natural menstrual cycle. I am not highly regimented with it but that is my general approach. In my experience, I havent found that there is a detriment of "taking too much" so have not worried about methodical dosing and just go how I feel and regularity of my cycles.