OP
Mauritio
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- Joined
- Feb 26, 2018
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Here's a recent study on liver fibrosis and policosanol in rats.
Policosanol was able to mostly prevent the fibrosis and "restore normal liver architecture" as the study authors phrased it.
It also increased anti-oxidants and reduced oxidative stress.
The study estimated annual deaths due to liver fibrosis at about 1,4 million per year. Liver fibrosis often progresses into liver cancer. So to reverse or ameliorate it, is quite big of a deal, especially since there's no approved medication for liver fibrosis as far as I know.
PTG = policosanol treated group
"Examination of the H&E-stained liver sections of NCG revealed normal hepatic architecture, normal lobular pattern with hepatocytes radiating from the central vein, and normal blood sinusoids. The hepatocytes showed homogenous cytoplasm and rounded nuclei with prominent nucleoli (Fig. 5A; Table 2). On the contrary, the liver of FG showed a loss of normal lobular pattern, variable degree of fibrosis, especially around the portal tract, and hepatocyte degeneration, including cloudy swelling of the hepatocytes, with congestion of blood sinusoids and capillaries (Fig. 5B; Table 2). Most liver tissues in the STG showed some degree of repair, including fewer collagen fibers than those observed in FG. However, some degree of cloudy swelling of hepatocytes with necrosis and congestion of blood capillaries was observed (Fig. 5C; Table 2). Notably, the PTG demonstrated a reduction in the histopathological lesions detected in CCl4 and STG, restoring normal liver architecture. It showed less sinusoidal congestion than both FG and STG. Moreover, only a small number of hepatocytes were vacuolated and slightly dilated, indicating mild vacuolar degeneration (Fig. 5D; Table 2)."
pubmed.ncbi.nlm.nih.gov
Policosanol was able to mostly prevent the fibrosis and "restore normal liver architecture" as the study authors phrased it.
It also increased anti-oxidants and reduced oxidative stress.
The study estimated annual deaths due to liver fibrosis at about 1,4 million per year. Liver fibrosis often progresses into liver cancer. So to reverse or ameliorate it, is quite big of a deal, especially since there's no approved medication for liver fibrosis as far as I know.
PTG = policosanol treated group
"Examination of the H&E-stained liver sections of NCG revealed normal hepatic architecture, normal lobular pattern with hepatocytes radiating from the central vein, and normal blood sinusoids. The hepatocytes showed homogenous cytoplasm and rounded nuclei with prominent nucleoli (Fig. 5A; Table 2). On the contrary, the liver of FG showed a loss of normal lobular pattern, variable degree of fibrosis, especially around the portal tract, and hepatocyte degeneration, including cloudy swelling of the hepatocytes, with congestion of blood sinusoids and capillaries (Fig. 5B; Table 2). Most liver tissues in the STG showed some degree of repair, including fewer collagen fibers than those observed in FG. However, some degree of cloudy swelling of hepatocytes with necrosis and congestion of blood capillaries was observed (Fig. 5C; Table 2). Notably, the PTG demonstrated a reduction in the histopathological lesions detected in CCl4 and STG, restoring normal liver architecture. It showed less sinusoidal congestion than both FG and STG. Moreover, only a small number of hepatocytes were vacuolated and slightly dilated, indicating mild vacuolar degeneration (Fig. 5D; Table 2)."
Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats - PubMed
Liver fibrosis is a prevalent liver disease that requires rapid and effective treatment prior to its progression to cirrhosis and liver damage. Recently, several reports have investigated the efficacy of phytotherapy using natural herbal extracts rather than synthetic drugs to treat several...
pubmed.ncbi.nlm.nih.gov
I will report back on my experiences when it gets here in 4 or 5 days...
