Niacin Was, Is, and Always will be Essential to Life and the Prevention of Cardiovascular Disease, Just for Starters
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The Vital Role of NAD+ and Niacin in Longevity and Well-being
- Thread starter Kimster
- Start date
Good review of potential benefits - only trouble with review papers is you have to dig in/go off the page in order to see study designs - if the paper was written with bias (nearly all are) then who knows if study designs were solidNiacin Was, Is, and Always will be Essential to Life and the Prevention of Cardiovascular Disease, Just for Starters
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JohnHafterson
Member
Niacin ( nicotinic acid ) the flushing version can cause blood sugar issues. There are papers on it causing diabetes in certain people.
Use it long enough at certain doses and it may give you metabolic issues.
Mileage may very but when I use it my blood sugars shoot threw the roof BUT I'm an insulin dependent Type 1 diabetic so one's mileage may very.
I cannot use without needing higher does of insulin.
I have found benefits to it including increasing peripheral circulation and other things but I can't play around with blood sugar and insulin doses.
Use it long enough at certain doses and it may give you metabolic issues.
Mileage may very but when I use it my blood sugars shoot threw the roof BUT I'm an insulin dependent Type 1 diabetic so one's mileage may very.
I cannot use without needing higher does of insulin.
I have found benefits to it including increasing peripheral circulation and other things but I can't play around with blood sugar and insulin doses.
What doses have you used that started causing issues ?
JohnHafterson
Member
As low as 100-150 mg niacin dose increase blood sugar. Higher doses 250-500mg moreso.
Severe Reversible Hyperglycemia as a Consequence of Niacin Therapy
Hypocholesterolemic drug therapy has become a major focus of cardiovascular medicine because recent evidence has demonstrated that optimization of serum lipid levels results in decreased atherosclerotic cardiovascular risk. Niacin, a B-complex vitamin, is capable of lowering total serum...
jamanetwork.com
Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets - PubMed
The widely used lipid-lowering drug niacin is reported to induce hyperglycemia during chronic and high-dose treatments, but the mechanism is poorly understood. Recently, the niacin receptor [G-protein-coupled receptor, (GPR) 109a], has been localized to islet cells while its potential role...
pubmed.ncbi.nlm.nih.gov
Thank you for taking time to respond.As low as 100-150 mg niacin dose increase blood sugar. Higher doses 250-500mg moreso.
Severe Reversible Hyperglycemia as a Consequence of Niacin Therapy
Hypocholesterolemic drug therapy has become a major focus of cardiovascular medicine because recent evidence has demonstrated that optimization of serum lipid levels results in decreased atherosclerotic cardiovascular risk. Niacin, a B-complex vitamin, is capable of lowering total serum...
Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets - PubMed
The widely used lipid-lowering drug niacin is reported to induce hyperglycemia during chronic and high-dose treatments, but the mechanism is poorly understood. Recently, the niacin receptor [G-protein-coupled receptor, (GPR) 109a], has been localized to islet cells while its potential role...
Obviously in some cases it could cause blood sugar issiues and I wonder why that is.
By any chance you eat a higher fat diet?
Heard Chris Masterjohn talking about TMG and adding methyl donors to avoid the high blood sugar issues.
JohnHafterson
Member
Diet didn't didn't matter. Effect was the same regardless of what I ate.
Niacin lowers fatty acids in the blood. There's a rebound effect to increase fatty acids.
This causes a temporary insulin resistance in the body.
Niacin effects adrenaline, increases growth hormone which increases fatty acids and blood sugar among other things.
Mileage may vary among people and dose differences may yield different results.
Interesting about TMG. I like to keep things simple so taking another supplement to mitigate the effects of particular supplement seems complicated.
Also Ray cautioned against taking methyl donors. TMG can cause sleep issues among other things. But I know some people seem to benefit from it like it.
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