David PS
Member
Ray Peat does not write very much about melatonin. That my be in part because both tryptophan and serotonin are precursors to melatonin (see the second of the two links for a visual = oo1.png).
http://link.springer.com/article/10.1007/s002990000206/lookinside/000.png
http://link.springer.com/article/10.1007/s002990000206/lookinside/001.png
The case for topical melatonin is stated near the end of the article entitled "Oxidative Stress in Ageing of Hair"at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929555/#sec1-10title
also see [The influence ofmelatoninonhairphysiology].
[Article in German] [The influence of melatonin on hair physiology]. - PubMed - NCBI
Abstract
Melatonin, the pineal gland hormone and a strong antioxidant, has long been known, particularly in animal-experiment based research and the wool-producing industry, to be a potent regulatory neuroendocrine substance in relation tohairgrowth,haircolor andhaircycle, depending on light periods, seasonal rhythms, environmental factors and reproductive rhythms. Nevertheless, the biological mechanisms of this extremely versatile hormone, especially with regard to humanhairfollicles, are not fully understood. In recent years, however, essential knowledge has been gained on the melatoninergic system of the skin,melatoninlevels in keratinocytes andhairfollicles, extrapineal intrafollicularmelatoninsynthesis and noradrenalin-induced increase in synthesis, as well ashaircycle-dependent expression of the membrane-boundmelatoninreceptor MT2 and the nuclear receptor RORalpha. Functional data on the growth of humanhairboth in vitro and in vivo show thatmelatoninmight play an essential role inhairphysiology.
Another article is at http://www.ncbi.nlm.nih.gov/pubmed/19799039
[Protective effect ofmelatoninon oxidative stress inducing hair follicle injury in scald rat].
I don't see a downside to trying this for topically for a few months. I not sure exactly how. Any thoughts?
http://link.springer.com/article/10.1007/s002990000206/lookinside/000.png
http://link.springer.com/article/10.1007/s002990000206/lookinside/001.png
The case for topical melatonin is stated near the end of the article entitled "Oxidative Stress in Ageing of Hair"at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929555/#sec1-10title
also see [The influence ofmelatoninonhairphysiology].
[Article in German] [The influence of melatonin on hair physiology]. - PubMed - NCBI
Abstract
Melatonin, the pineal gland hormone and a strong antioxidant, has long been known, particularly in animal-experiment based research and the wool-producing industry, to be a potent regulatory neuroendocrine substance in relation tohairgrowth,haircolor andhaircycle, depending on light periods, seasonal rhythms, environmental factors and reproductive rhythms. Nevertheless, the biological mechanisms of this extremely versatile hormone, especially with regard to humanhairfollicles, are not fully understood. In recent years, however, essential knowledge has been gained on the melatoninergic system of the skin,melatoninlevels in keratinocytes andhairfollicles, extrapineal intrafollicularmelatoninsynthesis and noradrenalin-induced increase in synthesis, as well ashaircycle-dependent expression of the membrane-boundmelatoninreceptor MT2 and the nuclear receptor RORalpha. Functional data on the growth of humanhairboth in vitro and in vivo show thatmelatoninmight play an essential role inhairphysiology.
Another article is at http://www.ncbi.nlm.nih.gov/pubmed/19799039
[Protective effect ofmelatoninon oxidative stress inducing hair follicle injury in scald rat].
I don't see a downside to trying this for topically for a few months. I not sure exactly how. Any thoughts?