Unlike all the other studies I have seen this is an in vivo study, so it provides some guidelines on dosage. The
human equivalent dosage would be in the range of 200,000 - 250,000 IU of all-trans-retinoic acid (which is a metabolite of retinol). That is on the high end, but note that the treatment was for only one day. As such, higher doses of vitamin A can probably be used relatively safely as a quick way to bring estrogen under control in a day or two. Combining this with a higher dose of vitamin E will probably have additive effects, and you can add vitamin K2 but make you sure you take it at least 6-8 hours after taking vitamin E to avoid interference with absorption of either vitamin.
http://www.ncbi.nlm.nih.gov/pubmed/17161848
"...EE increased uterine weight and the coinjection of ATRA with EE significantly suppressed this effect 3 and 24 h after treatment. mRNA expression was examined during this 24-h period and the mRNA expression levels of estrogen receptor alpha (ER alpha), retinoic acid receptor beta (RAR beta), retinoid X receptor gamma (RXR gamma) and cellular retinol-binding protein I (CRBP I) were found to have significantly increased in the ATRA+EE group compared with those in the EE group. This is the first report on the antiestrogenic activity of ATRA determined using an in vivo adult rat uterotrophic assay. The up-regulation of RAR or RXR mRNA expression level was probably responsible for the antiestrogenic activity of ATRA."
human equivalent dosage would be in the range of 200,000 - 250,000 IU of all-trans-retinoic acid (which is a metabolite of retinol). That is on the high end, but note that the treatment was for only one day. As such, higher doses of vitamin A can probably be used relatively safely as a quick way to bring estrogen under control in a day or two. Combining this with a higher dose of vitamin E will probably have additive effects, and you can add vitamin K2 but make you sure you take it at least 6-8 hours after taking vitamin E to avoid interference with absorption of either vitamin.
http://www.ncbi.nlm.nih.gov/pubmed/17161848
"...EE increased uterine weight and the coinjection of ATRA with EE significantly suppressed this effect 3 and 24 h after treatment. mRNA expression was examined during this 24-h period and the mRNA expression levels of estrogen receptor alpha (ER alpha), retinoic acid receptor beta (RAR beta), retinoid X receptor gamma (RXR gamma) and cellular retinol-binding protein I (CRBP I) were found to have significantly increased in the ATRA+EE group compared with those in the EE group. This is the first report on the antiestrogenic activity of ATRA determined using an in vivo adult rat uterotrophic assay. The up-regulation of RAR or RXR mRNA expression level was probably responsible for the antiestrogenic activity of ATRA."