Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
"...VD3/VDR had a positive regulatory effect on Cyp11a1 expression and testosterone secretion. VDR promotes testosterone synthesis in male mice by up-regulating Cyp11a1 expression, which played an important role for male reproduction.
..."Cyp11a1 was mainly expressed in testis, and dominantly existed in murine Leydig cells. Furthermore, over-expression VDR and CYP11A1 significantly increased testosterone synthesis in mice Leydig cells."
--> So VD increases Pregnenolone as well since Cyp11a1/StArR is very upstream and first increases pregnenolone and then testosterone. So a topical application of vitamin D to the testicles should yield some nice steroidogenic results.
Has anybody tried that?
@Hans
..."Cyp11a1 was mainly expressed in testis, and dominantly existed in murine Leydig cells. Furthermore, over-expression VDR and CYP11A1 significantly increased testosterone synthesis in mice Leydig cells."
--> So VD increases Pregnenolone as well since Cyp11a1/StArR is very upstream and first increases pregnenolone and then testosterone. So a topical application of vitamin D to the testicles should yield some nice steroidogenic results.
Has anybody tried that?
@Hans
VDR promotes testosterone synthesis in mouse Leydig cells via regulation of cholesterol side chain cleavage cytochrome P450 (Cyp11a1) expression - PubMed
Active vitamin D3 (VD<sub>3</sub>) and Vdr interference treatment showed that VD<sub>3</sub>/VDR had a positive regulatory effect on Cyp11a1 expression and testosterone secretion. VDR promotes testosterone synthesis in male mice by up-regulating Cyp11a1 expression, which played an important role...
pubmed.ncbi.nlm.nih.gov