jag2594 wrote:Ray Peat doesn't give much way to the genetic determinism in todays medical culture. He believes in a lamarckian ideology. What were you symptoms before finding out of the gene mutation.
L-methylfolate and other activated B-vitamins probably have specific actions in the body regardless of the presence of genetic mutations or not. It would probably be helpful to study them outside the context of the genetic mutation, although the genetic mutation is what's garnered methylfolate and other activated B-vitamins so much attention lately.
My symptoms before knowing about the genetic mutation were about 10 years of chronic anxiety, major depression, suicidal ideation, mood swings, insomnia and digestive problems (constipation, diarrhea, acid reflux, difficulty swallowing, poor appetite). They've persisted after I started taking L-methylfolate, but I did notice that in about a week of taking 7.5mg of it a day the symptoms weren't nearly as bad as they used to be.
Probably the most notable thing I experienced was the reduction in outbursts of anger. I used to have outbursts pretty frequently but since I started the L-methylfolate the incidents of that have dropped significantly.
It's hard to know how much I can attribute to the L-methylfolate, but I notice that when I've forgotten to take it for a week or two I tend to get extremely depressed and suicidal and feel a lot more irritable. Part of that could be that it throws me off just enough to make me stop taking care of myself, e.g., eating plenty of calories from sugar and saturated fat, getting enough protein, eating throughout the day and getting enough sleep, and then the cumulative effect of neglecting those things leads me into a downward spiral.
The therapeutic effect of L-methylfolate, mutation or not, is interesting to me, and I wonder how well it could fit into the context of energy production in the body, right alongside other B-vitamins like P-5-P and niacinamide.