cortisol

  1. haidut

    STUDY: Glycine may treat depression; MEDIA: Glycine may cause depression

    The level of misreporting in mainstream media is reaching criminal levels. For example, there have been many studies discovering that an increase in the activity of the serotonin transporter (SERT), which results in lower levels of extracellular serotonin, results in alleviation of depression or...
    • haidut
    • Thread
    • anxiety cancer cortisol depression glycine gpr158 stress taurine
    • Replies: 13
    • Forum: Scientific Studies
  2. haidut

    Hair glucocorticoid levels predict future cardiovascular disease (CVD)

    Ever since we launched our hair/nail steroid analysis service couple of years ago, I have been seeing a steadily increasing number of studies on using hair/nail steroid analysis to predict future risk and also assess severity of (already existing) many chronic conditions. While most of the...
    • haidut
    • Thread
    • cortisol cortisone cvd dhea hair long-term nail stress stroke
    • Replies: 6
    • Forum: Scientific Studies
  3. M

    Urgent Help To balance Cortisol Levels Repair Adrenals

    Can anyone recommend the best steps to help balance out cortisol & aid my adrenals? I wake up fine & feel great all morning which allows me to work hard, commit to my tasks, my patience is better, motivation, etc until about an hour or two after lunch & the rest of the day feels very low...
  4. T

    Adrenal Glandulars Source

    what is a good source for adrenal glandulars that contains cortisol? I’m aware of LifeGivingStore, but they go out of stock often and would like other options. Also, RLC labs A-Drenal, but I’m not sure if their product is real bovine adrenal cortex or just parts of the gland that don’t...
  5. haidut

    Atherosclerosis linked to high estrogen/cortisol/serotonin, low androgens

    The findings of the study are not surprising, but I wanted to post it on the blog since it is one of the few studies I have seen that examined more than one of the "sickness" mediator levels in a major chronic conditions such as cardiovascular disease (CVD), and found all of them to be elevated...
    • haidut
    • Thread
    • 5-ht atherosclerosis cortisol cvd estrogen hypogonadism pulmonary disease serotonin
    • Replies: 0
    • Forum: Scientific Studies
  6. Mr Joe

    Famous young influencer announce assisted suicide (DID)

    In the following thread a girl is talking about her "multiple personality disorder". She is saying basically that she was diagnosed depressive at the age of 8 and then suffered from "malnutrition". Later on, she was diagnosed with multiple personality disorder. And now she is pointing that one...
    • Mr Joe
    • Thread
    • brain cortisol metabolic stress serotonin ssri suicide thyroid
    • Replies: 10
    • Forum: Mental Issues
  7. haidut

    Cells preferentially accumulate Pregnenolone (P5), Progesterone (P4), and DHEA

    A study not directly dealing with disease, though its findings are probably relevant for all diseases. It demonstrates that in addition to the so-called "active transport", which we have been told is the dominant mechanism in steroid absorption and intracellular relevance, there also exists a...
    • haidut
    • Thread
    • androgens cortisol dhea estrogen intracellular p4 p5 pregnenolone progesterone uptake
    • Replies: 3
    • Forum: Scientific Studies
  8. Mr Joe

    Fraud Case Report : Hydrocortisone + Acetazolamide

    I am trying to dig Dr. Peat mention of Acetazolamide to help retain CO2. I've found a recent article : "We report a novel presentation of deficit in anterior pituitary function with variable immune deficiency (DAVID) syndrome in a healthy young girl presenting in Addisonian crisis with raised...
    • Mr Joe
    • Thread
    • acetazolamide co2 cortisol intracranial intracranial pressure metabolism
    • Replies: 2
    • Forum: CO2, Bag Breathing
  9. haidut

    Fasting decreases androgens, increases aldosterone (and possibly cortisol/estrogens) in women

    I often get criticized that I rely too much on animal studies, so here is a human one that should give the proponents of caloric restriction / fasting a pause. Even a short fast (24-48 hours) resulted in decreased androgen synthesis in women, while increasing aldosterone. In general, fasting...
    • haidut
    • Thread
    • aldosterone androgen caloric restriction cortisol estrogen fasting steroid
    • Replies: 1
    • Forum: Scientific Studies
  10. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
    • haidut
    • Thread
    • cortisol endotoxin glucocorticoid inflammation insulin lps tlr tlr4
    • Replies: 4
    • Forum: Scientific Studies
  11. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
    • haidut
    • Thread
    • allopregnanolone autism bromocriptine cortisol dopamine estrogen progesterone serotonin
    • Replies: 6
    • Forum: Scientific Studies
  12. cs3000

    11b-HSD1 inhibitors don't lower cortisol levels? increased ACTH response

    a lot of people try to lower cortisol this way. But these studies with a 11b-hsd1 inhibitor given to humans shows plasma cortisol levels stay the same regardless and ACTH levels rise. (ACTH rises in response to the lower conversion of cortisone -> cortisol from the enzyme inhibition, so with...
    • cs3000
    • Thread
    • 11b-hsd1 11β-hydroxysteroid dehydrogenase 11β-hydroxysteroid dehydrogenase type 1 acth cortisol enzyme inhibition lowering
    • Replies: 1
    • Forum: Scientific Studies
  13. haidut

    Niacinamide increases ATP/NAD, lower glucose/cortisol in humans

    A great new study demonstrating for the first time in a human experiment what hundreds of animal studies had suggested in the past. Namely, that niacinamide can serve as a reliable precursor to NAD+ and by raising the NAD/NADH ratio results in improved glucose metabolism and higher ATP levels...
    • haidut
    • Thread
    • atp cortisol glucose insulin nad niacinamide nicotinamide ribose
    • Replies: 18
    • Forum: Scientific Studies
  14. haidut

    "Endurance" exercise ages the vascular system of males by more than a decade

    A very interesting study, though I don't really agree with its findings that while "endurance" (in this case running) exercise damages male vascular system it is beneficial for the female one. The majority of intervention studies that looked at both sexes, across all age groups found that...
    • haidut
    • Thread
    • aging calcification cortisol cvd endurance exercise running vascular
    • Replies: 23
    • Forum: Scientific Studies
  15. Borz

    Confusion about T use

    In this recent talk Georgi is endorsing very high dose Testosterone use (100 mg a day), saying (according to the study) even 50 mg per day wasn't good enough. I'm very confused now, since I saw him recommend a physiological dose of about 5 mg per day. I use a few milligrams of T transscrotally...
    • Borz
    • Thread
    • cortisol progesterone testosterone
    • Replies: 27
    • Forum: Male Issues
  16. Epik

    How high to go on Emodin

    Hi all, I was just wondering if there are any down sides in taking maybe 1g of Emodin a day to force cortisol down. Any side effects or possible issues coming off Emodin? If so, what should be my max dose a day? Thanks!
  17. tastyfood

    How much do you pee per day?

    Serious question. Urine output is a good indicator for cortisol levels. It can be used to gauge the state of metabolism as well. I just took a 24 hour sample to Labcorp. The amount this time was 2.1L. I have struggled with large urine daily outputs for years. Frequent urination is really...
  18. haidut

    Stress (cortisol) makes even altruistic people selfish

    A great new study, which may explain a good deal of the general perception and several studies from the last decade claiming that societies in Western countries are becoming more selfish, combative/polarized, and even psychopathic. The more shocking finding of the study was that cortisol was...
    • haidut
    • Thread
    • altruism cortisol narcissism psychopathic selfish sociopathic stress
    • Replies: 4
    • Forum: Scientific Studies
  19. haidut

    Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

    A very interesting and very "controversial" (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine "mysteries"...
    • haidut
    • Thread
    • androgen atrophy cortisol fasting gonads hypogonadism stress
    • Replies: 15
    • Forum: Scientific Studies
  20. haidut

    DHT as anti-inflammatory as cortisol, but without the side effects

    As most of my readers know, glucocorticoids (synthetic or bioidentical) are widely used clinically and there is hardly a chronic conditions for which they are not prescribed even if only for managing brief "acute exacerbations". Despite mainstream medicine doing everything it can to conceal the...
    • haidut
    • Thread
    • androgen chronic cortisol dht gastritis glucocorticoid inflammation
    • Replies: 5
    • Forum: Scientific Studies
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