Koveras
Member
- Joined
- Dec 17, 2015
- Messages
- 720
Wrong the goal of pharmaceutical companies is to make as much money possible. Even if that means selling drugs that don't work or to the point that they do biological damage for example DES and thalidomide.
I lost thirty pounds while taking Cynomel while increasing my food intake. Unless you have taken Cynomel (Grossman brand not including other brands) most people won't believe how well it works for fat loss. I won't say its a magic bullet for obesity, with diet changes it can definitely help fat loss and I think cure obesity.
Fat oxidation has nothing to do with weight loss. In fact, it can cause weight gain by inhibiting mitochondrial respiration and releasing free fatty acids into the blood stream. 2'4-dinitrophenol is a chemical that was use in 1930's for weight loss. It can cure type 2 diabetes and obesity. The studies on it are clear, it does this through uncoupling mitochondria which increases carbon dioxide. It decrease free fatty acids and increases the use of glucose. Bromocriptine has most of the same effects but though the increasing dopamine and decreasing prolactin and serotonin. People with type 2 diabetes are more likely to be obese or overweight. The mechanisms behind this are due to the Randle cycle.
Exactly - the goal is to make as much money as possible. This would be accomplished by "producing a drug that will cause weight loss in the absence of conscious lifestyle changes". It's not very profitable to give a drug that doesn't do all that much for weight loss on it's own but enhances the results of a diet that's well adhered to.
Glad to hear to of your positive experience and results, although context is everything, and thyroid hormone may be more beneficial for some causes of obesity than for others.
Fat oxidation has everything to do with weight loss. Fat doesn't magically disappear from your body. Lipolysis releases stored fats, which are then oxidized.
You mentioned "it does this through uncoupling mitochondria"
Uncoupled mitochondria = same amount of fuel produces less ATP
ie. If 1 glucose produced 32 ATP before, maybe when mitochondria are very strongly uncoupled 1 glucose only produces 16 ATP.
In this example this means if you need 2000 calories per day normally, and now you need twice the fuel to produce the same amount of ATP, you now need 4000 calories per day.
If you increased your calorie intake to 4000 calories per day with your new metabolism, you would maintain your weight, because you're eating as much as you're burning despite being strongly "uncoupled"
If you continue to eat 2000 calories like you did before, and you are now burning 4000, that means that you are going to need to burn about 2000 calories worth of body fat to serve your energy needs.
If even you started day 1 with hugely full glycogen reserves of 500 grams (~2000 calories worth), you might delay a good portion of fat oxidation until day 2, when even if you ate 2000 calories of sugar, that would all get burned rather then stored, and now all you're left with is fat to oxidize to meet your needs.
Also I stand corrected on my "thyroid hormone decreases fat oxidation" point - it would be more correct to say that thyroid hormone favours carbohydrate oxidation when carbohydrates are available, but that it also increases fat oxidation (and lipolysis and free fatty acid blood levels) in a calorie or carbohydrate restricted state.
Feel free to do a literature review to check the effect of thyroid hormone on fat oxidation and lipolysis.