haidut
Member
Another point for caffeine, even though the reported effectiveness is weak. I always wondered why I seemed to get similar effects on breathing (shallower and more efficient) form caffeine and acetazolamide.
http://www.ncbi.nlm.nih.gov/pubmed/21612376
"...Caffeine and piperine were extracted and tested for inhibition of the human (h) cytosolic isoforms hCA I and II. The IC(50) values of caffeine against hCA I was of 55 mM, whereas that of piperine of 60 mM. The IC(50) values of caffeine and piperine against hCA II were of 2 mM. Although these are quite weak inhibitors they may constitute leads for developing tighter binding compounds."
It is probably worth a try to do a brown bag breathing after caffeine ingestion, or combine caffeine with acetazolamide, or pomegranate. Pomegaranate has several compounds that are quite potent carbonic anhydrase inhibitors.
http://en.wikipedia.org/wiki/Carbonic_a ... _inhibitor
"...Ellagitannins extracted from the pericarps of Punica granatum, the pomegranate, such as punicalin, punicalagin, granatin B, gallagyldilactone, casuarinin, pedunculagin and tellimagrandin I, are highly active carbonic anhydrase inhibitors."
http://www.ncbi.nlm.nih.gov/pubmed/8220326
http://www.ncbi.nlm.nih.gov/pubmed/21612376
"...Caffeine and piperine were extracted and tested for inhibition of the human (h) cytosolic isoforms hCA I and II. The IC(50) values of caffeine against hCA I was of 55 mM, whereas that of piperine of 60 mM. The IC(50) values of caffeine and piperine against hCA II were of 2 mM. Although these are quite weak inhibitors they may constitute leads for developing tighter binding compounds."
It is probably worth a try to do a brown bag breathing after caffeine ingestion, or combine caffeine with acetazolamide, or pomegranate. Pomegaranate has several compounds that are quite potent carbonic anhydrase inhibitors.
http://en.wikipedia.org/wiki/Carbonic_a ... _inhibitor
"...Ellagitannins extracted from the pericarps of Punica granatum, the pomegranate, such as punicalin, punicalagin, granatin B, gallagyldilactone, casuarinin, pedunculagin and tellimagrandin I, are highly active carbonic anhydrase inhibitors."
http://www.ncbi.nlm.nih.gov/pubmed/8220326