Its a bit old but I noted this sort of weird research seemingly showing actual in vivo tumor suppression by limiting carbohydrates in the precencse of cold exposure- what on earth is going on here:You are right, this study simply focused on LDH. I should have clarified in my post that actual glucose deprivation has been done before and it also failed. The chemical used was 2-deoxy-glucose (2-DG).
2-Deoxy-D-glucose - Wikipedia
The human studies I have seen with 2-DG show no more than 30% response rate (partial remission), and after a few months the tumors resume growth. There is also some preliminary evidence showing 2-DG triggers metastases even in people with previously localized tumors.
Brown-fat-mediated tumour suppression by cold-altered global metabolism
Brown-fat-mediated tumour suppression by cold-altered global metabolism - Nature
Mild cold exposure activates a substantial amount of brown adipose tissue (BAT) in a patient with cancer, reducing tumour-associated glucose uptake, and activation of BAT in mice inhibits the growth of tumours by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells.
www.nature.com
Brown-fat-mediated tumour suppression by cold-altered global metabolism - Nature
Mild cold exposure activates a substantial amount of brown adipose tissue (BAT) in a patient with cancer, reducing tumour-associated glucose uptake, and activation of BAT in mice inhibits the growth of tumours by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells.
www.nature.com