tonto
Member
- Joined
- Nov 29, 2014
- Messages
- 60
Ray Peat has mentioned that early life stress can have long term ramifications for the serotonin system, and possibly the way stress is handled later in lift.
This TED Talk "talks" around this subject but does a good job showing the range of medical problems related to child trauma -
Here are 2 articles which represent Peat's view. This may explain why adults are not as resilient to stress as we may have thought in many cases.
Effects of prenatal maternal stress on serotonin and fetal development
(http://www.sciencedirect.com/science/article/pii/S0143400415300941)
Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology
(Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology)
This TED Talk "talks" around this subject but does a good job showing the range of medical problems related to child trauma -
Here are 2 articles which represent Peat's view. This may explain why adults are not as resilient to stress as we may have thought in many cases.
Effects of prenatal maternal stress on serotonin and fetal development
(http://www.sciencedirect.com/science/article/pii/S0143400415300941)
Fetuses are exposed to many environmental perturbations that can influence their development. These factors can be easily identifiable such as drugs, chronic diseases or prenatal maternal stress. Recently, it has been demonstrated that the serotonin synthetized by the placenta was crucial for fetal brain development. Moreover, many studies show the involvement of serotonin system alteration in psychiatric disease during childhood and adulthood. This review summarizes existing studies showing that prenatal maternal stress, which induces alteration of serotonin systems (placenta and fetal brain) during a critical window of early development, could lead to alteration of fetal development and increase risks of psychiatric diseases later in life. This phenomenon, termed fetal programming, could be moderated by the sex of the fetus. This review highlights the need to better understand the modification of the maternal, placental and fetal serotonin systems induced by prenatal maternal stress in order to find early biomarkers of psychiatric disorders.
Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology
(Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology)
Despite more than 60 years of research in the role of serotonin (5-HT) in psychopathology, many questions still remain. From a developmental perspective, studies have provided more insight into how 5-HT dysfunctions acquired in utero or early in life may modulate brain development. This paper discusses the relevance of the developmental role of 5-HT for the understanding of psychopathology. We review developmental milestones of the 5-HT system, how genetic and environmental 5-HT disturbances could affect brain development and the potential role of DNA methylation in 5-HT genes for brain development.