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Okay move on .Protodioscin isn’t aromatizable or non-aromatizable, it’s not a hormone, it’s a saponin.
I’ve read virtually all studies on all herbs you can think of
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Okay move on .Protodioscin isn’t aromatizable or non-aromatizable, it’s not a hormone, it’s a saponin.
I’ve read virtually all studies on all herbs you can think of
Think in context man... Nobody says it's a Hormone, just that it is a DHEA analog (look at the molecule structure). Saying "non-aromatizable" is just a metaphore to say that it has very similar properties than DHEA but without the risk of getting converted to estrogen. So, yes, let's move on...Protodioscin isn’t aromatizable or non-aromatizable, it’s not a hormone, it’s a saponin.
I’ve read virtually all studies on all herbs you can think of
Okay move on .
That's fantastic! What exactly did they take?I know of 4 that were not able to do much except lie in bed all day (not even watch TV). All of those people are now employed and have active social lives. Two of them (one female and one male) started families (not with each other).
I've just finished reading this whole thread (looking for suramin info) and some of you are definitely onto what the research is proving, and some of you are way off. Sadly, I should've taken notes while going through. I'll be condensing information (of research) over the next few months, but for now.
ME/cfs (please let's lose the CFS term) is for sure not high estrogen. My God, if it were teen and young woman would be the main group falling, not pre-menopausel women - who's E is falling.
Undiagnosed low thyroid is NOT causing ME, but probably the majority of people with ME have subclinical hypoT and would benefit with treatment. The cause can be many things, one even being Empty Sella Syndrome.
Exercise is clinically proven (in blood, heart, brain scans and more) to be HARMFUL, not helpful, in ME - even graded exercise. (The authors of PACE are narcissistic, ego-maniacs. Their science has been disputed many times.)
This is a great channel. Look for the last year, and the green background videos. A very good one by Dr. Jarred Young on neuro-inflammation. SolveCFS
This channel, especially the conferences posted 5 and 8 months ago: Open Medicine Foundation - OMF
This is a 29 video playlist (harder to track on a smart t.v.). It is also presenters to an NIH conference. Some are more tech, some are more guarded, IDK, it's just different, but still very good info
This channel is by a very well known ME doc Lucinda Bateman, I've watched several of her presentations on other channels. I see they just posted two videos which sound controversial, I haven't seen them. Bateman Horne Center
ME/cfs has been greatly ignored since 1992 when two British psychiatrist wrote a paper stating it was psychosomatic. This was not only a massively poorly done study, even for its time, but as we know it has made it very difficult to gain research and credible traction sadly not only ruining the lives of millions of people, but also their families. Serious research restarted about 5 years ago, largely privately funded. I believe the private funding is exactly why they are making good headway. What I'm worried about is they are getting close to getting more NIH funding which will lead to pharma funding and there goes not only collaboration, but honesty.
Interesting note, some of these researchers are studying Gulf War Syndrome side by side with ME. The symptoms are largely the same. The biology is amazingly similar in about 75% of areas, and distincly different in about 25% of areas.
What the researchers haven't seemed to connect is a possible link between connective tissue disorders and ME, even though it (collagen mutations) appear in some of their research. And the hEDS researchers aren't, to my knowledge, collaborating with the ME researchers. EDS research is also largely funded and both British and US agency are pulling out of the EDS area, the Brits are pushing it more to psychosomatic. And finally, Fibro (which most scientist differentiate from ME) which is diagnosed 5x more than ME and has NIH funding is being pushed more and more as psychosomatic with a recent study on "Flower arranging to ease pain".
Good question and I'm not sure yet as far as current research (see note at bottom). I have hundreds if not into the thousands of pages right now, much of it simply saved to go back and condense. I've started a spreadsheet for genes to look at, even though we know it's not one gene, but they are finding common clusters.So what do you think are the most promising substances/lifestyle interventions for CFS?
I'm just starting to put a list of genes into a spreadsheet, but have several hundred bookmarked, or tabs open.@Momentum What are the krebs genes you are referring to and what thyroid protocol did you use?
Lifting weights is the solution
So what do you think are the most promising substances/lifestyle interventions for CFS?
I've just finished reading this whole thread (looking for suramin info) and some of you are definitely onto what the research is proving, and some of you are way off. Sadly, I should've taken notes while going through. I'll be condensing information (of research) over the next few months, but for now.
ME/cfs (please let's lose the CFS term) is for sure not high estrogen. My God, if it were teen and young woman would be the main group falling, not women in their 40's and up - who's E is falling.
Undiagnosed low thyroid is NOT causing ME, but probably the majority of people with ME have subclinical hypoT and would benefit with treatment. The cause can be many things, one even being Empty Sella Syndrome.
Exercise is clinically proven (in blood, heart, brain scans and more) to be HARMFUL, not helpful, in ME - even graded exercise. (The authors of PACE are narcissistic, ego-maniacs. Their science has been disputed many times.)
Deconditioning is also not at all the situation, as many fall ill at the peak of their health
The recent research is clear ME/cfs is not psychosomatic, it is not one virus, one gene mutation or one auto-immune illness. It is a complex disease of multiple failures, mostly likely caused by a predisposition and triggered by..........a host of things.
This is a great channel. Look for the last year, and the videos that the thumbnail has a mint green background. A very good one by Dr. Jarred Young on neuro-inflammation. SolveCFS
This channel, especially the conferences posted 5 and 8 months ago: Open Medicine Foundation - OMF
This is a 29 video playlist (harder to track on a smart t.v.). It is also presenters at an NIH conference. Some are more tech, some are more guarded, IDK, it's just different, but still very good info - many of the same players worth getting to know.
This channel is by a very well known ME doc, Lucinda Bateman, I've watched several of her presentations on other channels. I see they just posted two videos which sound controversial, I haven't seen them. Bateman Horne Center
ME/cfs has been greatly ignored since 1992 when two British psychiatrist wrote a paper stating it was psychosomatic. This was not only a massively poorly done study, even for its time, but as we know it has made it very difficult to gain research and credible traction sadly not only ruining the lives of millions of people, but also their families. Serious research re-started about 5 years ago, largely privately funded. I believe the private funding is exactly why they are making good headway (and great new tech). What I'm worried about is that they are getting closer to getting more NIH funding which will lead to pharma funding and there goes not only collaboration, but honest studies.
Interesting note, some of these researchers are studying Gulf War Syndrome side by side with ME. The symptoms are largely the same. The biology is amazingly similar in about 75% of areas, and distinctly different in about 25% of areas.
What the researchers haven't seemed to connect is a possible link between connective tissue disorders and ME, even though it (collagen mutations) appear in some of their research. And the hEDS researchers aren't, to my knowledge, collaborating with the ME researchers. EDS research is also largely privately funded; but both British and US agencies are pulling out of the EDS arena, the Brits are pushing it more to the pain being psychosomatic. I believe they have calculated the cost of rising awareness, and a dramatic increase in possible hEDS diagnosis could be on the horizon - and that will be expensive. And finally, Fibro (which most scientist differentiate from ME) is diagnosed 4x more than ME and has NIH funding is being pushed more and more as psychosomatic with a recent study on "Flower arranging to ease pain". I believe that Fibro is diagnosed so much more than CFS because who wants a CFS diagnosis? - you will be mocked and dismissed. And almost as many men are diagnosed with ME as women, but 4x as many women as men are diagnosed with CFS (the same thing). Again, what man wants an ME dx? How likely will a doctor dx a man with ME over a CFS? There is a lot at play here.