I just read this post Prevention of Hair Loss in Men
then I did quick research to found this:
"Chronic caffeine intake has been shown to increase the receptors of serotonin (26-30% increase), GABA (65% increase), and acetylcholine (40-50%).
This may contribute to the elevated mood and perceived increase in energy we feel after a coffee (which makes espresso a handy pre-workout drink).
Despite increasing receptors, caffeine also inhibits the release of GABA, which contributes to our feeling of alertness.
Chronic caffeine intake also increases the sensitivity of serotonin receptors.
In other words, receptors specific to serotonin are more responsive to serotonin present in the synaptic cleft —
it’s sort of like installing a bigger satellite dish to catch more of an existing signal. One study showed a decrease in serotonin release,
but an increase in serotonin reuptake, leading to an overall increase in serotonin levels. (Think of it as the brain’s natural recycling.)"
If coffee is really Serotonin agonist, why is so praised here ?
Also if coffee increase GABA receptors, but in same time inhibits GABA release, what will be the effect when taken with Phenibut. Is it synergist
(65% increase GABA receptors) or antagonist to Phenibut?
So I have taken Phenibut like 10 times with no effects whatsoever (small, medium, large doses) and the first couple of times I wasn't coffee drinker yet.
But I smoke tobacco. Is it possible cigarettes to offset Phenibut effects?
then I did quick research to found this:
Coffee and hormones: Here's how coffee really affects your health. - Precision Nutrition
Many North Americans now consume coffee in large quantities, which can damage our neuroendocrineimmune system. Read more about coffee and hormones in this article.
www.precisionnutrition.com
"Chronic caffeine intake has been shown to increase the receptors of serotonin (26-30% increase), GABA (65% increase), and acetylcholine (40-50%).
This may contribute to the elevated mood and perceived increase in energy we feel after a coffee (which makes espresso a handy pre-workout drink).
Despite increasing receptors, caffeine also inhibits the release of GABA, which contributes to our feeling of alertness.
Chronic caffeine intake also increases the sensitivity of serotonin receptors.
In other words, receptors specific to serotonin are more responsive to serotonin present in the synaptic cleft —
it’s sort of like installing a bigger satellite dish to catch more of an existing signal. One study showed a decrease in serotonin release,
but an increase in serotonin reuptake, leading to an overall increase in serotonin levels. (Think of it as the brain’s natural recycling.)"
If coffee is really Serotonin agonist, why is so praised here ?
Also if coffee increase GABA receptors, but in same time inhibits GABA release, what will be the effect when taken with Phenibut. Is it synergist
(65% increase GABA receptors) or antagonist to Phenibut?
So I have taken Phenibut like 10 times with no effects whatsoever (small, medium, large doses) and the first couple of times I wasn't coffee drinker yet.
But I smoke tobacco. Is it possible cigarettes to offset Phenibut effects?