Maybe just use proviron by itself?
I just said the opposite.
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Maybe just use proviron by itself?
Anything after the pilot study. Are more being scheduled?
I just said the opposite.
Plent of guys on trt notice an acceleration of hai loss
I meant it can still be interesting in the sense that we're always told dht and the likes when supplemented will increase ARs. I don't know if others on here think AR are overexpressed in prostate cancer.
Btw not sure ray gives any particular importance to receptors, speak ing about anti serotonin chemicals upregulating serotonin receptors he said "I think their place is heavily ideologized, i.e., tending to deflect from thorough investigation of the situation"
I agree with Haidut, the decades long treatment and expplainations of prostate cancer was blatant malpractice. I still would like to stress 3ß-diol here. Even if the study is in favour of the AR-expression increasing stronger androgens DHT and the synthetic one, in a healthy non cancerous orgnism DHT gets metbaolized back and forth to 3a- and 3ß-diol respecively. They are androgens with high affinity to ERß, 3ß-diol especially, and thus contribute significantly to androgens protective effects by acting where in estrogen dominant, pathological states Estrogens would act.
A different thing is a highly advance cancer as discussed in the study, here 3a and 3ß-diol seem to act a bit different to DHT or the synthetic, though all compounds reduce tumor growth
So, in line with previous discussions on the forum about androgens increasing AR expression. [...]
Why would the effects in human not have to take into account the metabolites and how dht/androsterone is dealt with by the body? In vitro result should be very different in that case.
Its crazy that bio-identical DHT is banned in the US.
@haidut
And anyone else interested, of course.
Posting this in the first DHT thread that came up. This study shows that administration of DHT to female guinea pigs for 60 days @1mg/kg (although it was dissolved in peanut oil) increased DHEA-S levels (pretty substantially) as well as DHEA and even more interestingly had a trophic effect on the zona reticularis of the adrenal gland. If i’m not mistaken, this is the layer of the gland that functions in the production of DHEA. Moreover, pregnenolone was elevated, and of course the DHT was elevated yet estradiol wasnt elevated. In fact the 60 day animals became acyclic, perhaps due to an overall decrease in estrogen from DHT’s antagonism to aromatase? Its crazy that bio-identical DHT is banned in the US.
Effects of dihydrotestosterone treatment on adrenal gland function and morphology in adult female guinea-pigs. - PubMed - NCBI