rockarolla
Member
Through a ton of self experimentation I've found out that in order to increase metabolism on a high calorie diet all TLR4(endotoxin) inhibitors should be greatly reduced. And it does not really matter which ones exactly are currently saturating endotoxin receptors as antagonists, whether its vitamin C or A or D(D25), or some supplement like lutein(also as a food source), or polyphenols, etc.
And some TLR4 antagonists (ex: lutein) have a huge half life so sometimes the result could be postponed and is evident only after several months after withdrawal.
reducing PUFA is also critical:
as well as fiber:
Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells - Inflammation
etc, etc - i have a huge list of TLR4 antagonists and if anyone is interested i can post it here with refs to research papers.
And some TLR4 antagonists (ex: lutein) have a huge half life so sometimes the result could be postponed and is evident only after several months after withdrawal.
reducing PUFA is also critical:
Omega-3 polyunsaturated fatty acid supplementation and the response to evoked endotoxemia in healthy volunteers
Fish oil-derived n-3 PUFA may improve cardiometabolic health through modulation of innate immunity; however, findings in clinical studies are conflicting. We hypothesized that n-3 PUFA supplementation would dose-dependently reduce the systemic inflammatory ...
www.ncbi.nlm.nih.gov
as well as fiber:
Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells - Inflammation
etc, etc - i have a huge list of TLR4 antagonists and if anyone is interested i can post it here with refs to research papers.