Candeias
Member
- Joined
- Apr 29, 2018
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- 220
Carbohydrate Derived Fulvic Acid: An in vitro Investigation of a Novel Membrane Active Antiseptic Agent Against Candida albicans Biofilms
"All planktonic C. albicans isolates tested were susceptible to all four antifungal drugs, with MIC90 for CHD-FA, VRZ, AMB, and CSP of 0.125% and 0.125 mg/l, respectively (Table (Table1).1). MIC50 and MIC90 refer to the MICs of ≥50/90% of isolates inhibited by each antifungal, respectively. When the sessile activity of each compound was compared to planktonic cells in terms of MIC90 fold change, CHD-FA was the most effective (2×), followed by caspofungin (4×), amphotericin B (64×) and voriconazole (>2048×). Both planktonic and sessile cells showed comparable MIC’s for all 50 strains tested.The biofilm rate of kill of CHD-FA was assessed, where dose and time dependent killing was observed. Greater killing was observed after 1, 2, and 4 h at 4 × SMIC50 in comparison to 1 and 2 × SMIC50 where a decrease in viability of 65 and 89% was observed. After 24 h treatment no differences were observed between each concentration, with an approximate final 92% kill. When each antifungal was compared at 4 × SMIC50 then CHD-FA displayed the quickest killing compared in ascending order to AMB, VRZ and CSP, which after 2 h was 89, 61, 18, and −2%, respectively"
I read many positive anecdotal reports on forums on Fulvic Acid, is anyone an expert on this?
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