Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc
Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice):
*Reverses effects of aging / restores youth
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00838-7
(hesperidin breaks down to some hesperitin in the body)
changes their genetic expression to match that seen in youth more closely. it wasnt profound enough to move them back completely to youth of course. but shifted them more towards that across many measures
its actually a great effect. some measures were profound enough to match or exceed youthful measures.
glycogen synthesis restored completely, reversal of otherwise increased glycolysis.
it improved muscle function, lymphocyte count,
their metabolism completely restored and even EXCEEDED youthful levels in oxygen consumption, CO2 production and basal energy expenditure during light period, & all measures went up significantly higher than non treated aged rats. their mitochondria is thriving again
their lean body mass % went way up.
and their muscle performance went up a lot. their heart function improved.
lifespan increase:
amazing study
amazing effects for 1 thing with a great safety profile (as long as you watch out for the CYP450 enzyme inhibition when taking at the same time as some medications)
2 things that stood out on baseline measures after , there's a slight drop in magnesium. and a big increase in fasting insulin.
"The dose used in this study is an achievable dose in humans and is a human equivalent dose of 491 mg/60 kg/day" , over 3 to 6 months.
Hesperi tin is harder to find as a supplement than hesperidin. but the body breaks hesperidin down into hesperitin
"Bioavailability Is Improved by Enzymatic Modification of the Citrus Flavonoid Hesperidin in Humans: A Randomized, Double-Blind, Crossover Trial"
~180mg 2.92mg/kg body weight of hesperidin cMax in blood of hesperetin = 1.07
~80mg 1.21mg/kg body weight of hesperitin cMax in blood of hesperetin = 2.66
takes 7 hours to get there taking hesperidin vs hesperetin 30 mins
so assuming thats linear , 80mg hesperetin = 450mg hesperidin for same dose of hesperitin in blood. need 5.5x hesperidin to get same amount of hesperitin.
491mg hesperetin = 2.5g hesperidin.
but not sure about going that high when hesperidin has effects at low doses even. maybe hesperidin could work similar at the same dose ~500mg if high dose is not tolerated.
Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice):
*Reverses effects of aging / restores youth
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00838-7
(hesperidin breaks down to some hesperitin in the body)
^ that makes it sound like a superpower compound lol.Hesperetin, a promising Cisd2 activator, when orally administered late in life, enhances Cisd2 expression and prolongs healthspan in old mice.
Secondly, hesperetin functions mainly in a Cisd2-dependent manner to ameliorate age-related metabolic decline, body composition changes, glucose dysregulation, and organ senescence.
Finally, a youthful transcriptome pattern is regained after hesperetin treatment during old age.
changes their genetic expression to match that seen in youth more closely. it wasnt profound enough to move them back completely to youth of course. but shifted them more towards that across many measures
its actually a great effect. some measures were profound enough to match or exceed youthful measures.
glycogen synthesis restored completely, reversal of otherwise increased glycolysis.
it improved muscle function, lymphocyte count,
their metabolism completely restored and even EXCEEDED youthful levels in oxygen consumption, CO2 production and basal energy expenditure during light period, & all measures went up significantly higher than non treated aged rats. their mitochondria is thriving again
To study the anti-aging and beneficial effects of hesperetin on age-related metabolic decline, we examined the whole-body energy metabolism and body composition of the old mice treated with hesperetin. Our results reveal that the VO2, CO2 and EE of Veh-treated old (28-month old) WT mice were significantly decreased compared to young (3-month old) WT mice. Importantly and intriguingly, hesperetin treatment for 6 months attenuates these age-related reductions that affect the whole-body metabolism of the old mice during their dark period
their lean body mass % went way up.
and their muscle performance went up a lot. their heart function improved.
^ holy ***tInterestingly, after 3 months of hesperetin treatment (Fig. 5K),
the ultrastructural damage to the aged heart had largely disappeared and seem to have been reversed
resulting in the ICD features and mitochondria now resembling the situation observed in the hearts of 3-month WT mice
lifespan increase:
8.7% , up to 13.9% lifespan increase (and thats starting supplementation at old age, probably more lifespan increase starting middle age).The median lifespan of the hesperetin-treated WT mice was increased by 2.25 months (8.7%; from 25.95- to 28.2-month old) relative to Veh-treated WT mice (p = 0.04), with the maximum lifespan increase being 4.1 months (13.9%; from 29.5- to 33.6-month old)
amazing study
amazing effects for 1 thing with a great safety profile (as long as you watch out for the CYP450 enzyme inhibition when taking at the same time as some medications)
2 things that stood out on baseline measures after , there's a slight drop in magnesium. and a big increase in fasting insulin.
"The dose used in this study is an achievable dose in humans and is a human equivalent dose of 491 mg/60 kg/day" , over 3 to 6 months.
Hesperi tin is harder to find as a supplement than hesperidin. but the body breaks hesperidin down into hesperitin
"Bioavailability Is Improved by Enzymatic Modification of the Citrus Flavonoid Hesperidin in Humans: A Randomized, Double-Blind, Crossover Trial"
~180mg 2.92mg/kg body weight of hesperidin cMax in blood of hesperetin = 1.07
~80mg 1.21mg/kg body weight of hesperitin cMax in blood of hesperetin = 2.66
takes 7 hours to get there taking hesperidin vs hesperetin 30 mins
so assuming thats linear , 80mg hesperetin = 450mg hesperidin for same dose of hesperitin in blood. need 5.5x hesperidin to get same amount of hesperitin.
491mg hesperetin = 2.5g hesperidin.
but not sure about going that high when hesperidin has effects at low doses even. maybe hesperidin could work similar at the same dose ~500mg if high dose is not tolerated.
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