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A few people report that they feel significantly worse with vitamin D supplementation. It might be either because the dose is too high for them or that they convert it very rapidly to the active form, which can have detriments in large amounts.
This study found that excess vit D lowered all brain waves. They did say it was very high doses, equivalent to 3.5k/kg HED, but it caused these effects after just 4 days. They speculate that it's through an increase in serum calcium concentration.
"Thus, the present study describes the electroencephalographic changes caused by supraphysiological doses of vitamin D in the brain electrical dynamics, and the electrocardiographic changes. After 4 days of treatment with vitamin D at dose of 25,000 IU/Kg, the serum calcium levels found was increased in comparison with control group. The ECoG analysis found a reduction in wave activity in the delta, theta, alpha and beta frequency bands. For ECG was observed changes with shortened QT follow-up, which could be related to serum calcium concentration. This study presented important evidence about the cerebral and cardiac alterations caused by high doses of vitamin D, indicating valuable parameters in the screening and decision-making process for diagnosing patients with symptoms suggestive of intoxication."
This study found that excess vit D lowered all brain waves. They did say it was very high doses, equivalent to 3.5k/kg HED, but it caused these effects after just 4 days. They speculate that it's through an increase in serum calcium concentration.
100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats - PubMed
Low plasma levels of vitamin D causes bone mineral change that can precipitate osteopenia and osteoporosis and could aggravate autoimmune diseases, hypertension and diabetes. The demand for vitamin D supplementation becomes necessary; however, the consumption of vitamin D is not without risks...
pubmed.ncbi.nlm.nih.gov