Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
I wanted to add those 2 quotes to the discussion maybe it helps someone:
I think the overall message of the studies on caffeine is this - if one can't handle a decent dose of caffeine (200mg - 400mg), taken with food if necessary, without getting a stress response then glycogen stores are poor. Ability to store glycogen is largely determined by liver function, and liver function is a good approximator of overall health. Poor liver function means high estrogen, poor PUFA detoxification, poor conversion of T4 into T3, etc. Most people over 30 have some form of NAFLD - i.e. fatty liver. I posted a study long time ago showing that as little as 2mg/kg human dose taken for 2 weeks restored proper liver fat metabolism and got the liver lean again. Here is that study.
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. - PubMed - NCBI
So, maybe the "adaptation" the studies above found was simply this - improved liver function and ability to store glycogen. Btw, thyroid hormone also triggers a stress response in people with poor liver function. So, the effect of caffeine is not to somehow innately cause a stress reaction but simply to push a poorly functioning organism beyond its ability to handle energetic demands. As liver function improves (and how long it takes is unique to each person), so does the ability to handle caffeine.
I used to be super sensitive to anything that could stimulate me the slightest, so I couldn’t take most supplements and I was deathly afraid of caffeine as it would ruin my day if I ingested it. Began taking kuinone for maybe 2 months now and i’m able to take all kinds of supplements without any anxiety. Better glycogen storage maybe?
Great supplement @haidut