Around 15:00 in the interview, Ray Peat says:
“Both the seed oil industry and the estrogen industry found it very convenient to sell the idea that vitamin E is merely an anti-oxidant. So from the 1940s on, d-alpha tocopherol was identified as how to measure the value of vitamin E, because it was the most anti-oxidant. So until just fairly recently, the only component that they measured was the alpha component. But it turns out that the gamma and others have very distinct, more important biological activities, including opposition to estrogen.”
@haidut has posted studies suggesting that alpha tocopherol is an aromatase inhibitor and an estrogen receptor antagonist, and has said in a few threads that alpha likely deserves more credit than gamma for vitamin E's anti-estrogenic effects, e.g.:
“I prefer the alpha-tocopherol heavy variety as it favors the anti-estrogen effects of vitamin E. Gamma tocopherol seems to affect mostly NO and LOX, which are also good aspects. So, I personally prefer mixed tocopherols with more alpha because the focus will be on estrogen blockade while also getting the anti-NO and LOX inhibition effects. High-gamma mixed tocopherols tend to have mostly anti-inflammatory effects but much less of pro-progesterone and anti-estrogen effects.”
Source: Retinil - Liquid Vitamin A
Curious about whether RP would prefer high gamma or high alpha mixed tocopherols for blocking estrogen.
He states that gamma and the other components are more important in blocking estrogen. So why ask ? I mean its obvious that the owner of Ideallabs and Ray Peat have different opinions on the question of vitamin E so it's important to be cautious with what people say.
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