Mauritio
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- Joined
- Feb 26, 2018
- Messages
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This is such an interesting study, once again underlining something RP has said for decades.
Rats that have a bacteria-free gut (germ free) dont experience the same weight gain that they normally experience on a "western" a.k.a. high PUFA diet. Not only that, but feeding them high fructose, which normally leads to fatty liver or even liver steatosis is absent in mice with a germ free gut.
This is interesting because it proves fructose does not cause fatty liver!
So it looks like fructose is feeding the wrong microbes, which then leads to an increase in serotonin and finally liver illnesses.
There is another recent study which shows exactly that: increasing serotonin (by lowering the serotonin transporter SERT), leads to a decrease in metabolism, weight gain and liver steatosis. The mice consumed 21% less calories, but still weighed more, which is saying something about serotonin's anti-metabolic effects.
Rats that have a bacteria-free gut (germ free) dont experience the same weight gain that they normally experience on a "western" a.k.a. high PUFA diet. Not only that, but feeding them high fructose, which normally leads to fatty liver or even liver steatosis is absent in mice with a germ free gut.
- Lack of liver steatosis in germ-free mice following hypercaloric diets - PubMed"GF housing results in an impaired weight gain and a lack of steatosis following a WSD. Also the fructose-induced steatosis, which is unrelated to body weight changes, is absent in GF mice."
This is interesting because it proves fructose does not cause fatty liver!
So it looks like fructose is feeding the wrong microbes, which then leads to an increase in serotonin and finally liver illnesses.
There is another recent study which shows exactly that: increasing serotonin (by lowering the serotonin transporter SERT), leads to a decrease in metabolism, weight gain and liver steatosis. The mice consumed 21% less calories, but still weighed more, which is saying something about serotonin's anti-metabolic effects.
"SERT-/- mice showed increased weight gain compared with SERT+/+ mice when fed a WSD ± F for 12 weeks (p < 0.05), whereby SERT-/- mice exhibited reduced energy (-21%) intake. Furthermore, SERT knockout resulted in a more pronounced liver steatosis (p < 0.05), enhanced levels of endotoxin in portal vein plasma (p < 0.05), and increased liver expression of Tnf and Myd88 (p < 0.05), when mice were fed a WSD ± F. "
- Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western-style diet - PubMed"Our data demonstrate that SERT knockout causes weight gain, liver steatosis, and leaky gut, especially in mice fed a WSD. Therefore, SERT induction could be a novel therapeutic approach to improve metabolic diseases associated with intestinal barrier dysfunction."