I decided to try LDN for the first time to see if it can help me with my dysthymia I've been battling for a long time. 2 nights ago was my first dose of it. Good thing I read that longecity thread that is referenced in this thread. Prior to reading it, I was going to just start at the 1.5mg dose, then after reading it, I decided to start with a lower dose. I did 500mcg and even on this dose, it severely effected my sleep. Hard to say exactly how much sleep I did get, but my guess is probably no more than about an hour. It was strange, it felt like I didn't get any sleep at all, but I did remember some dreaming. Woke up with a dry mouth, and felt some extra tension in my high cheek bones. The whole next day <yesterday> I felt worse than normal. I didn't start feeling better until shortly before I was going to go to bed at night. I decided to skip my dose last night and start anew tonight with even a smaller dosage to see how things go. I understand sleep can be effected when starting LDN, but I'm just going to have to do some experimenting on the dosage.