Hi
Has anyone heard any definitive answers about mangosteen.I stumble on it recently on my never ending search for anti oestrogen foods. I have read clinical studies which say it is a potent aromatase inhibitor and also that it is a serotonin antagonist. All the marketing hype says it has a high tryptophan content but I can't find any clinical research to validate this. My own experience is that it has a very strong antidepressant, action noticeable within an hour. Since reading Ray Peat and my new held belief that serotonin excess is a bad thing, I have been avoiding precursors as much as possible. I find I have a reaction that I used to get from ssri's and also 5HTP, in that the mangosteen causes my muscles to tense and contract in an uncomfortable way. So I'm wondering if anyone can verify the high tryptophan content of this food as that would make sense as to the reaction I'm having. Otherwise it sounds like an amazing supplement to address the above concerns and it also stabilises blood sugar very well and fast, I've tested that. and it has a host of other clinical studies predominately related to cancer benefits. I also can't find any Peat references to the xanthones, which is the active ingredient found in the fruit rind.
Also can some one clarify some basics around serotonin agonists and antagonists for me, forgive my ignorance.
1/ If a serotonin antagonist is blocking the uptake of serotonin wouldn't that increase plasma levels, in a similar way to ssri's inhibiting reuptake ?
2/ Is it possible for something to be a serotonin antagonist and also have a high tryptophan content at the same time?
Thanks
Has anyone heard any definitive answers about mangosteen.I stumble on it recently on my never ending search for anti oestrogen foods. I have read clinical studies which say it is a potent aromatase inhibitor and also that it is a serotonin antagonist. All the marketing hype says it has a high tryptophan content but I can't find any clinical research to validate this. My own experience is that it has a very strong antidepressant, action noticeable within an hour. Since reading Ray Peat and my new held belief that serotonin excess is a bad thing, I have been avoiding precursors as much as possible. I find I have a reaction that I used to get from ssri's and also 5HTP, in that the mangosteen causes my muscles to tense and contract in an uncomfortable way. So I'm wondering if anyone can verify the high tryptophan content of this food as that would make sense as to the reaction I'm having. Otherwise it sounds like an amazing supplement to address the above concerns and it also stabilises blood sugar very well and fast, I've tested that. and it has a host of other clinical studies predominately related to cancer benefits. I also can't find any Peat references to the xanthones, which is the active ingredient found in the fruit rind.
Also can some one clarify some basics around serotonin agonists and antagonists for me, forgive my ignorance.
1/ If a serotonin antagonist is blocking the uptake of serotonin wouldn't that increase plasma levels, in a similar way to ssri's inhibiting reuptake ?
2/ Is it possible for something to be a serotonin antagonist and also have a high tryptophan content at the same time?
Thanks