R J
Member
- Joined
- Sep 30, 2020
- Messages
- 414
Is this product topical only? Does it absorb orally well or does MCT mean it gets metabolized by liver first?
Last edited:
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Oral progesterone should be dissolved in longer chain fatty acids not MCT oil. If it’s dissolved in MCT oil and taken orally, most of it will go to the liver and be metabolized so the progesterone may not reach the tissues. If the progesterone is dissolved in long chain fats, then it will get incorporated into chylomicrons and go directly to the blood stream and tissues which is similar to endogenously produced progesterone.
Interesting, I’ll just use it topically then. It’s for my dog so I will just rub it on her stomach and private parts where there’s no fur. I wonder if the tocopherol in the MCT mix helps some of it cross with chylomicrons if taken orally. Sucks to know I probably wasted a bottle giving it to her orally! Thanks!
Here is a direct quote from Peat’s November 2019 newsletter (Money, progesterone & life):Interesting, I’ll just use it topically then. It’s for my dog so I will just rub it on her stomach and private parts where there’s no fur. I wonder if the tocopherol in the MCT mix helps some of it cross with chylomicrons if taken orally. Sucks to know I probably wasted a bottle giving it to her orally! Thanks!
It looks like topical is more than 10% as serum levels don’t seem to show that more is being absorbed by tissues Trouble with Topical Progesterone and Testing (Jan 2014) Townsend Letter for Doctors & Patientswhat he meant was it needs to be dissolved in vitamin E, and taken orally.
Topically it only has 10% absorption.
Orally in MCT oil is just less effective.
i cant find the article, but I used to post it on this forum that said what I just did
I think this was the article.
https://annarborholistichealth.com/wp-content/uploads/2020/06/Progesterone-.pdf
Onasnatural sell it in vitamin E
Then why the h*ll is his own progesterone product dissolved in MCT then ? Wouldn't it be equally costly to replace them with longer chain saturated fats?
Then why the h*ll is his own progesterone product dissolved in MCT then ? Wouldn't it be equally costly to replace them with longer chain saturated fats?
Then why the h*ll is his own progesterone product dissolved in MCT then ? Wouldn't it be equally costly to replace them with longer chain saturated fats?
Doesn't the 10% oral absorption apply only if its taken without high fat meal? And also im not sure if its studied with micronized version or not? So if you take the progest-e or micronized progesterone orally with high fat meal it should be much higher?Im pretty sure even tho MCT is said to be absorbed by portal vein that some does get absorbed by chylomicrons or in some way where it doesn’t go right to liver. I cant find where I read it but it was suggested that despite the common consensus that some MCT does get absorbed differently.
So I was too hasty to say I “wasted” a bottle by giving it orally because I did notice my dog had deeper sleep. In any case I will probably try topical this time anyways because it sounds like it’s far more effective than 10%
There is some evidence but it’s likely more progesterone would reach the blood stream if it’s dissolved in longer chain fatty acids. Medium-chain fatty acids: evidence for incorporation into chylomicron triglycerides in humans - PubMedIm pretty sure even tho MCT is said to be absorbed by portal vein that some does get absorbed by chylomicrons
Doesn't the 10% oral absorption apply only if its taken without high fat meal? And also im not sure if its studied with micronized version or not? So if you take the progest-e or micronized progesterone orally with high fat meal it should be much higher?
There is some evidence but it’s likely more progesterone would reach the blood stream if it’s dissolved in longer chain fatty acids. Medium-chain fatty acids: evidence for incorporation into chylomicron triglycerides in humans - PubMed