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https://www.researchgate.net/profil...ealthy_men/links/541812070cf203f155ad92c0.pdf
We found a decrease in sperm concentration and motility below the normal range in 2 of 8 men enrolled in a double-blind study of daily treatment. Moreover, in these 2 men, we observed a decrease in seminal and blood E2 levels with a concomitant increase in testosterone:E2 ratios. Since the sequence of medications in these 2 men was placebo followed by melatonin, we conclude that the decrease in semen quality was associated with melatonin administration
A direct inhibitory effect of melatonin on sperm motility was suggested in several studies (Irez et al, 1992; Van Vuuren et al, 1992). It was suggested that melatonin inhibition might proceed by acting on sperm membranes or by binding to the tubulin of the sperm flagellum to decrease motility (Irez et al, 1992).
The ability of melatonin to suppress experimentally induced lipid peroxidation in sperm membranes was studied in infertile men.
Sperm incubated with melatonin showed a reduced rate of lipid peroxidation (Gavella and Lipovac, 2000). A more plausible explanation is that by inhibiting epididymal and testicular aromatase, melatonin caused a decrease in locally produced E2 and an increase in the androgen:estrogen balance, resulting in decreased sperm motility and concentration. E2 given daily to male rats induced inhibitory effects on spermatogenesis and serum testosterone levels.
We found a decrease in sperm concentration and motility below the normal range in 2 of 8 men enrolled in a double-blind study of daily treatment. Moreover, in these 2 men, we observed a decrease in seminal and blood E2 levels with a concomitant increase in testosterone:E2 ratios. Since the sequence of medications in these 2 men was placebo followed by melatonin, we conclude that the decrease in semen quality was associated with melatonin administration
A direct inhibitory effect of melatonin on sperm motility was suggested in several studies (Irez et al, 1992; Van Vuuren et al, 1992). It was suggested that melatonin inhibition might proceed by acting on sperm membranes or by binding to the tubulin of the sperm flagellum to decrease motility (Irez et al, 1992).
The ability of melatonin to suppress experimentally induced lipid peroxidation in sperm membranes was studied in infertile men.
Sperm incubated with melatonin showed a reduced rate of lipid peroxidation (Gavella and Lipovac, 2000). A more plausible explanation is that by inhibiting epididymal and testicular aromatase, melatonin caused a decrease in locally produced E2 and an increase in the androgen:estrogen balance, resulting in decreased sperm motility and concentration. E2 given daily to male rats induced inhibitory effects on spermatogenesis and serum testosterone levels.