Piperine is added to some supplements, and black pepper is common in food cupboards / with dinners. Apparently can be 3% piperine - 5% piperine in black pepper but varies alot
Feeding ~100mg-150mg piperine human equivalent to rats is toxic to testicles. lowers testosterone (+ progesterone) & leydig cell function
Feeding every 4 days shows significant toxic effect on testicles & testosterone / progesterone.
and 1x a week milder but still a toxic effect, -10% testosterone
the 1x a week dose is closest to typical intake for someone who eats black pepper multiple times a week or takes a supplement with piperine
so assuming spread out has same impact, ~15mg a day for the E7D damage level. or ~30mg for the E4D damage / testosterone reducing level
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in vitro studies have shown anti growth effects on cancers, but its not just the toxicity because some state estrogen B receptor increases with estrogen A decrease.
estrogen receptor part different than what i expected. wonder if its estrogenic in normal brain cells or not
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Its serotonergic so has potential to raise irritability dissociation depression etc
Antidepressant-like effects of piperine and its derivative, antiepilepsirine - PubMed
shows raises serotonin without raising dopamine ,
might think serotonin is rising because of receptor antagonism some studies reference it but from personal experience the acute effect is very serotonergic. and not anti depressant
so if there is a different longer term effect through 5ht1a (anti serotonin) receptor increase as response to the serotonin increase, its a shitty way to get there with a toxic molecule. and if its the bdnf response theres other things that create that
also complexities to consider about where the serotonin is being raised preferably
I did an experiment a while ago trying black pepper for unrefreshing sleep. think it was 1/2 or 1/4 teaspoon.
it didnt help sleep quality and i felt absolutely SH*T for 2 days after,
Clearly potent serotonergic state which was very recognisable -
it caused major irritability + drowsy fatigue + flat mood + dissociated weird quality to experience. I said out loud "man i actually feel autistic rn wtf". then i looked into it and read the link between mao-a inhibition and serotonin rise, and autism - serotonin - mao-a loss association.
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B
From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency
Feeding ~100mg-150mg piperine human equivalent to rats is toxic to testicles. lowers testosterone (+ progesterone) & leydig cell function
Our study result suggests that piperine disrupted the functional integrity of the testis by altering the germ cell markers, antioxidant
status, and testicular hormones. These biochemical study results were further reinforced by histopathological observation of hypospermatogenesis on piperine treatment.
However, the toxic effects of piperine were reversed affer the drug‑free withdrawal period of 60 days.
Feeding every 4 days shows significant toxic effect on testicles & testosterone / progesterone.
and 1x a week milder but still a toxic effect, -10% testosterone
the 1x a week dose is closest to typical intake for someone who eats black pepper multiple times a week or takes a supplement with piperine
so assuming spread out has same impact, ~15mg a day for the E7D damage level. or ~30mg for the E4D damage / testosterone reducing level
-
in vitro studies have shown anti growth effects on cancers, but its not just the toxicity because some state estrogen B receptor increases with estrogen A decrease.
estrogen receptor part different than what i expected. wonder if its estrogenic in normal brain cells or not
-
Its serotonergic so has potential to raise irritability dissociation depression etc
Antidepressant-like effects of piperine and its derivative, antiepilepsirine - PubMed
^In contrast, chronic treatment of PIP only enhanced the serotonin level in the hypothalamus and hippocampus but did not influence the dopamine level. The MAO activity assay also indicated that PIP and AES showed a minor MAO inhibitory activity
shows raises serotonin without raising dopamine ,
might think serotonin is rising because of receptor antagonism some studies reference it but from personal experience the acute effect is very serotonergic. and not anti depressant
so if there is a different longer term effect through 5ht1a (anti serotonin) receptor increase as response to the serotonin increase, its a shitty way to get there with a toxic molecule. and if its the bdnf response theres other things that create that
also complexities to consider about where the serotonin is being raised preferably
I did an experiment a while ago trying black pepper for unrefreshing sleep. think it was 1/2 or 1/4 teaspoon.
it didnt help sleep quality and i felt absolutely SH*T for 2 days after,
Clearly potent serotonergic state which was very recognisable -
it caused major irritability + drowsy fatigue + flat mood + dissociated weird quality to experience. I said out loud "man i actually feel autistic rn wtf". then i looked into it and read the link between mao-a inhibition and serotonin rise, and autism - serotonin - mao-a loss association.
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B
From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency
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