Prevention of Influenza episodes with Colostrum compared with vaccination in Healthy and High-Risk Cardiovascular subjects

[cs3000]

Colostrum is great for protective immunity,
4.6 days of disease in 3 months when taking colostrum daily vs 11.3 days in vaccine group vs 13.2 days in untreated group
also 2x the amount of people didnt get infections vs the other groups.

"colostrum is at least 3 times more effective than vaccination to prevent flu"
The days of disease in the colostrum group were 30% of those recorded in the vaccination group
https://www.researchgate.net/public...ects_The_Epidemiologic_Study_in_San_Valentino

The use of colostrum, on the contrary, is practically free of side effects. Furthermore, the dosage
used in this study is very low, corresponding to 400 mg of colostrum.

In many instances, flu starts from the intestinal tract, and protection in situ may be one of the advantages given by colostrum.
Local activity in the gut may be the most important factor. However, rotavirus antibody were shown to survive during the passage
through the gut, which may also determine systemic immunity​

works especially well in people with poor immunity,
in this case study giving just 1g a day = 0 respiratory tract infections vs 5 the previous year *
Influences of bovine colostrum on nasal swab microbiome and viral upper respiratory tract infections
** doesnt work as well if taking after viral load already high , but this gives great effects for preventative immunity works at "low" dose ~1g daily

 

[Rinse & rePeat]

“Colostrum contains many components that have immunomodulatory and antimicrobial properties. You can read a bit more about this here. Colostrum has been researched since the 1970's because of its ability to not only bind to a wide range of pathogenic viruses and bacteria, but also to many allergens.”

Anti-Viral Properties of Colostrum for Respiratory Tract Infections - Invivo Healthcare

A digestion from the comprehensive review paper: Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection with specific attention to viruses and upper respiratory tract infections.

invivohealthcare.com

“It's important to note that some foods, including eggs, milk, and certain types of meat, may provide a natural source of colostrum and its immune-supporting components, such as immunoglobulins.”

https://www.codeage.com/blogs/education/colostrum-exploring-the-benefits-and-sources-of-first-milk#:~:text=It's%20important%20to%20note%20that%20some%20foods%2C%20including%20eggs%2C%20milk,supporting%20components%2C%20such%20as%20immunoglobulins.

“There are many variables that impact colostrum quality, including nutrition, the time the cow is milked, heat stress, and stage of lactation. A study from Iowa State University suggests that a minimum 30% of dairy calves in the USA are currently being fed colostrum classified below industry standards for IgG content and are at a greater risk of FPT, mortality, and morbidity (Morrill et al. 2011).

Other production mammals such as piglets face the same issues as calves for colostrum quality. Studies have shown that on average 25% of pigs with a colostrum intake below 200 g usually die. In pigs with a colostrum intake below 100 g, mortality was as high as 65% (Devillers et al. 2011). Giving spray-dried bovine colostrum to other animals such piglets has been shown (Sty et al. 2006) to help protect against gut dysfunction and inflammation. It may be possible that using bovine colostrum for piglets could help supplement sow colostrum. Research has also been done in foals with an enhanced bovine colostrum supplementation (Fenger et al. 2016).“

Colostrum Antibodies, Egg Antibodies and Monoclonal Antibodies Providing Passive Immunity for Animals

Passive immunity can be provided to animals by several sources of antibodies including from colostrum, avian eggs, and monoclonal sources. These antibodies have been shown protect production and companion animals from a number of pathogens. This chapter reviews the...

link.springer.com

 

[Rinse & rePeat]

“Just as immune protection is transferred in utero in mammals or passively by a lactating mother via colostrum, hens passively transfer protection to their young by secreting immunoglobulin and other immune factors into their eggs for use by the hatching chick. The transfer of chicken immunoglobulins from the hen’s serum to the yolk and from the yolk to the chick is analogous to cross-placental transfer of IgG from the mammalian mother to its offspring.”

Colostrum Antibodies, Egg Antibodies and Monoclonal Antibodies Providing Passive Immunity for Animals

Passive immunity can be provided to animals by several sources of antibodies including from colostrum, avian eggs, and monoclonal sources. These antibodies have been shown protect production and companion animals from a number of pathogens. This chapter reviews the...

link.springer.com

 

[Mauritio]

Nice, thanks for sharing guys. I'm dealing with recurrent respiratory infections so i might give this a try.
Do you know if capsules work just as well?

 

[Rinse & rePeat]

Nice, thanks for sharing guys. I'm dealing with recurrent respiratory infections so i might give this a try.
Do you know if capsules work just as well?

“The quality of colostrum can vary depending on the source and processing methods used. Look for a supplement that uses high-quality colostrum that is minimally processed to preserve its natural bioactive compounds. Ideally, the colostrum should be sourced from grass-fed cows that are free from hormones and antibiotics.”

https://www.buoyhealth.com/blog/supplements/best-colostrum-supplement#:~:text=The%20quality%20of%20colostrum%20can,free%20from%20hormones%20and%20antibiotics.

 

[Mauritio]

I found this study interesting.
Colostrum potently reduces serotonin in times of stress (exercise here), so this might be one of its pro-immunity factors . It also increases running performance by about 60% in the right dosage. The most effective dose for all effects was about 1200mg HED

Effect colostrum serum on 5-HT expression in dorsal raphe. Upper: Photomicrograph of 5-HT-positive cells. The scale bar represents 250 μm (x4). Lower: number of 5-HT-positive cells in each group. A: control group B: exercise group, C: exercise and 50mg/kg of colostrum serum treatment, D: exercise and 100mg/kg of colostrum serum treatment, E: exercise and 200mg/kg of colostrum serum treatment. The data are presented as the mean ± standard error of the mean (S.E.M). * represents p < 0.05 compared to the control group. # represents p < 0.05 compared to the exercise group.

Effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei of exercised rats

The central fatigue hypothesis suggests that exhaustion, or the maximum level of exercise, induces excessive stress and increases serotonin concentrations in the brain, which in turn decreases central nervous system (CNS) function and induces fatigue. ...

www.ncbi.nlm.nih.gov

 

[Mauritio]

“The quality of colostrum can vary depending on the source and processing methods used. Look for a supplement that uses high-quality colostrum that is minimally processed to preserve its natural bioactive compounds. Ideally, the colostrum should be sourced from grass-fed cows that are free from hormones and antibiotics.”

https://www.buoyhealth.com/blog/supplements/best-colostrum-supplement#:~:text=The%20quality%20of%20colostrum%20can,free%20from%20hormones%20and%20antibiotics.

Thanks!

 

[Rinse & rePeat]

Thanks!

Sure thing!

 

[Mauritio]

Lactoferrin might also be a big factor in colostrums anti-viral effects:

"Our study provides evidence that bLf prevents SARS-CoV-2 infection by combining SARS-CoV-2 spike protein RBD and inhibiting coronaviruses' RdRp activity, and may be a promising candidate for the treatment of coronavirus disease 2019."
- Bovine lactoferrin inhibits SARS-CoV-2 and SARS-CoV-1 by targeting the RdRp complex and alleviates viral infection in the hamster model - PubMed

- Lactoferrin for prevention of common viral infections - PubMed.

 

[Mauritio]

"These findings support the notion that lactoferrin may be a promising candidate for systemic treatment of influenza by locally acting on the intestine and microbiota."
- Lactoferrin Alleviates Inflammation and Regulates Gut Microbiota Composition in H5N1-Infected Mice - PubMed

 

[David PS]

Bovine Colostrum for Veterinary and Human Health Applications: A Critical Review​

 

[cs3000]

I found this study interesting.
Colostrum potently reduces serotonin in times of stress (exercise here), so this might be one of its pro-immunity factors . It also increases running performance by about 60% in the right dosage. The most effective dose for all effects was about 1200mg HED
Effect colostrum serum on 5-HT expression in dorsal raphe. Upper: Photomicrograph of 5-HT-positive cells. The scale bar represents 250 μm (x4). Lower: number of 5-HT-positive cells in each group. A: control group B: exercise group, C: exercise and 50mg/kg of colostrum serum treatment, D: exercise and 100mg/kg of colostrum serum treatment, E: exercise and 200mg/kg of colostrum serum treatment. The data are presented as the mean ± standard error of the mean (S.E.M). * represents p < 0.05 compared to the control group. # represents p < 0.05 compared to the exercise group.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508057/

nice nice. interesting dose response as well (wonder if lower doses work better for immunity too - studies in OP only used 1g or less)

“Colostrum contains many components that have immunomodulatory and antimicrobial properties. You can read a bit more about this here. Colostrum has been researched since the 1970's because of its ability to not only bind to a wide range of pathogenic viruses and bacteria, but also to many allergens.”

Other production mammals such as piglets face the same issues as calves for colostrum quality. Studies have shown that on average 25% of pigs with a colostrum intake below 200 g usually die. In pigs with a colostrum intake below 100 g, mortality was as high as 65% (Devillers et al. 2011).
https://link.springer.com/chapter/10.1007/978-3-030-04624-8_18

damn, big importance early

In many instances, flu starts from the intestinal tract, and protection in situ may be one of the advantages given by colostrum. Local activity in the gut may be the most important factor. [endotoxin protection for less symptoms?] However, rotavirus antibody were shown to survive during the passage through the gut, which may also determine systemic immunity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1320312/?page=2
It was observed that piglets were equally protected from rotaviral diarrhea when they were fed diets made from either unheated milk that came from a cow immunized against porcine rotavirus or from a cow that was not immunized. Because of this observation, we examined four pools of "normal" cows' colostrum and 58 samples of "normal" cow's milk for the presence of antibody to rotavirus.

since rotaviral antigens are shared by isolates from many different species of mammals (humans included), neonates in general could also be protected by diets made in part with cow's colostrum. We sought to exploit the cow's entire lactation as a source of a readily available dietary rotaviral antibody.

All pools of colostrum, collected in four different years, had immunofluorescent antibody titers of 1:100 to rotavirus. Seventy-two percent of the samples of milk were also positive--titer no higher than 1:10. Antibodies to rotavirus were found in cow's milk at a creamery prior to but not after pasteurization. Rotaviral antibodies were detected in one out of eight brands of milk bought at the market--perhaps indicating inadequate pasteurization for this brand.